What is fetal anaerobic metabolism?

EVIDENCE of a form of metabolism in which less oxygen per unit of energy is used in the fetus and newborn than in older animals has been recognized for some time. An “anaerobic” metabolism leading to the traditional “oxygen deficit” in muscle activity is well established.

What is fetal metabolism?

the fetal metabolism exerts in the control of fetal growth. The assessment of any interrelationships. has to be inferential, largelythrough an analysis of differences in fetal metabolism associated with. variations in the fetal growth rate. There appear to be three major factors regulating fetal growth.

What causes fetal respiratory acidosis?

Maternal causes of chronic fetal acidosis include reduced oxygenation of maternal blood, such as in severe respiratory or cardiac disease, or reduced blood flow to the placenta as in connective tissue diseases—for example, systemic lupus erythematosus—and pre-eclampsia.

Can fetal glucose metabolism occur in anaerobic conditions?

Experiments in the past century have shown that both unicellular and multicellular organisms can metabolize glucose and other sugars anaerobically. Meyerhof (1930) was one of the first to demonstrate that extracts of mammalian muscle can convert glycogen to lactic acid under anaerobic conditions.

When does aerobic metabolism begin in the fetus?

Development of aerobic metabolism in utero: Requirement for mitochondrial function during embryonic and fetal periods. For citation purposes: Baker CN, Ebert SN. Development of aerobic metabolism in utero: Requirement for mitochondrial function during embryonic and fetal periods. OA Biotechnology 2013 Apr 01;2 (2):16.

What happens to fetal cells in the absence of oxygen?

In the absence of oxygen, fetal cells may continue to produce the energy required for maintenance of basic homeostatic functions during a few more minutes, by resorting to anaerobic metabolism. However, the latter yields much less energy than aerobic metabolism and results in the production of lactic acid.

How is the amount of oxygen needed in a fetus determined?

The amount of oxygen necessary is determined by basic metabolic requirements, fetal size, and fetal activity. 10 So long as oxygen supply and demand are balanced, oxygen will support metabolism of glucose aerobically to produce energy, known as adenosine triphosphate (ATP). By-products of aerobic metabolism are water and carbon dioxide.

When does the body switch to aerobic metabolism?

Critical examination of the idea that anaerobic metabolism is the primary generator of ATP throughout gestation in mammals suggests that this may not be entirely true since the developmental switch to aerobic metabolism actually occurs well before birth.

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