What is a consensus sequence in transcription?

A consensus sequence is a sequence of DNA, RNA, or protein that represents aligned, related sequences. In DNA molecules, consensus sequences are useful for representing short elements that are binding sites for other molecules. Such elements may be recognized by, for example, proteins in transcriptional control.

What is consensus sequence?

Comprises the most commonly encountered nucleotides found at a specific location in DNA or RNA.

What consensus sequences are found in bacterial promoters?

Bacterial. In bacteria, the promoter contains two short sequence elements approximately 10 (Pribnow Box) and 35 nucleotides upstream from the transcription start site. The sequence at -10 (the -10 element) has the consensus sequence TATAAT. The sequence at -35 (the -35 element) has the consensus sequence TTGACA.

What consensus sequences are most commonly found in bacteria to initiate transcription?

Initiation of transcription requires promoter regions, which are specific nucleotide consensus sequences that tell the σ-factor on RNA polymerase where to bind to the DNA. The promoters are usually located 15 to 19 bases apart and are most commonly found upstream of the genes they control.

Which is an example of a consensus sequence?

Consensus sequence. A consensus sequence is an ideal promoter sequence in DNA – in E. coli, for example, two are found, a -35 sequence and a -10 sequence.

What are the consensus sequences in prokaryotic transcription?

Prokaryotic Promoters and Initiation of Transcription. At the -10 and -35 regions upstream of the initiation site, there are two promoter consensus sequences, or regions that are similar across all promoters and across various bacterial species. The -10 consensus sequence, called the -10 region, is TATAAT.

What makes a promoter look like a consensus sequence?

Any mutation allowing a mutated nucleotide in the core promoter sequence to look more like the consensus sequence is known as an up mutation. This kind of mutation will generally make the promoter stronger, and thus the RNA polymerase forms a tighter bind to the DNA it wishes to transcribe and transcription is up-regulated.

Where is the consensus sequence located in SUR1?

Consensus sequences for several transcription factors are present on the SUR1 promoter located in the first 140 bp of the 5′-flanking region. They include Sp1, E-boxes, and AP2 Clark and Docherty (1993) Madsen et al (1997) Ashfield and Ashcroft (1998).

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