What are the indications for NSAIDs?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are available by prescription and over-the-counter (OTC). They are used to relieve fever and pain, such as those associated with headaches, colds, flu, and arthritis. Examples of prescription NSAIDs include ibuprofen, naproxen, diclofenac, and celecoxib.

Are Coxibs NSAIDs?

Coxibs (also known as COX-2 inhibitors) are a type of non-steroidal anti-inflammatory drug (NSAID). Coxibs, like other NSAIDs, relieve pain and reduce inflammation.

Which NSAIDs are selective COX-2 inhibitors?

COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) | FDA.

Is NSAIDs inhibit the activity of the enzyme cyclooxygenase?

Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages.

What is the difference between NSAIDs and COX-2 inhibitors?

Since the prostaglandins that protect the stomach and promote blood clotting also are reduced, NSAIDs can cause ulcers in the stomach and intestines, and increase the risk of bleeding. Unlike older NSAIDs that block both COX-1 and COX-2, the newer COX-2 inhibitors only block the COX-2 enzyme.

Is ibuprofen an NSAID?

Types of NSAIDs NSAIDs are available as tablets, capsules, suppositories (capsules inserted into the bottom), creams, gels and injections. Some can be bought over the counter from pharmacies, while others need a prescription. The main types of NSAIDs include: ibuprofen.

Are all NSAIDs COX-2 inhibitors?

COX-2 inhibitors (such as Celebrex and Bextra) are a type of NSAID and are the most commonly prescribed drugs for arthritis. COX-2 inhibitors are also prescribed for many forms of back pain….

What is the difference between COX-1 and COX-2?

In the gastrointestinal tract, COX-1 maintains the normal lining of the stomach and intestines, protecting the stomach from the digestive juices. 4 The enzyme is also involved in kidney and platelet function. COX-2, on the other hand, is primarily found at sites of inflammation.

What are the uses of COX-2 selective NSAIDs?

The uses of COX-2 selective NSAIDs in specific disorders are also discussed elsewhere (see appropriate topic reviews). (See “NSAIDs: Therapeutic use and variability of response in adults” and “NSAIDs: Pharmacology and mechanism of action” and “Nonselective NSAIDs: Overview of adverse effects” .)

What do you need to know about COX-2 inhibitors?

Cox-2 inhibitors. What are Cox-2 inhibitors? Cyclooxygenase-2 (COX-2) inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that specifically blocks COX-2 enzymes. Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that relieve pain and fever and reduce inflammation.

Which is the best class of coxibs tablets?

COXIBS ` BNF 4.7.1, 10.1.1 Class: Non-opioid analgesic, NSAID (selective COX-2 inhibitor). COXIBS ` BNF 4.7.1, 10.1.1 Class: Non-opioid analgesic, NSAID (selective COX-2 inhibitor). Indications:Coxibs available in tablet form are all licensed for use in osteo-arthritis and rheumatoid arthritis.

How are coxibs used to treat inflammatory pain?

COX-2 is massively expressed in inflammation, and is responsible for the production of prostaglandins associated with inflammatory pain. As with non-selective NSAIDs, the coxibs exert an analgesic effect by inhibiting COX-2.