What are insulin secretagogues examples?

Glyburide, glipizide and glimepiride are examples of some of the more commonly used sulfonylureas. This group of medicines lowers your blood sugar by stimulating beta cells to make more insulin. The SFUs are generally taken once or twice daily. For these medicines to work, your pancreas must have beta cells that work.

Does insulin promote hypoglycemia?

The hormone insulin lowers blood sugar levels when blood sugar is too high. If you have type 1 or type 2 diabetes and need insulin to control your blood sugar, taking more insulin than you need can cause your blood sugar level to drop too low and result in hypoglycemia.

Are DPP 4 inhibitors insulin secretagogues?

The commonly available drugs to treat diabetes are of several groups including insulin secretagogues (like sulfonylureas), Glucagon-like Peptide-1(GLP-1) agonists, Dipeptidyl Peptidase-4 (DPP-4) inhibitors, meglitinides, insulin sensitizers (like thiazolidinediones, biguanides), glucosidase inhibitors, and SGLT2 …

What does secretagogue mean in medical terms?

stimulates secretion
Medical Definition of secretagogue : a substance that stimulates secretion (as by the stomach or pancreas)

What are the risks of taking insulin secretagogues?

The main complication of insulin secretagogues is hypoglycemia. Risk factors for hypoglycemia are aging, past history of cardiovascular disease or stroke, impaired renal function, and reduced food intake (Box 5.1). The risk of hypoglycemia is also related to the pharmacological half-life of the medication and to the time it is bound to the SUR.

Which is the best insulin secretagogue for hypoglycemia?

As a result, nateglinide is the secretagogue with the most specific activity in lowering postprandial glucose and the lowest risk of hypoglycemia. However, because of its lack of effect on fasting glucose, its efficacy in lowering HbA1c is modest. The main complication of insulin secretagogues is hypoglycemia.

How are hypoglycemics used to treat type 1 diabetes?

Hypoglycemics are used to treat high blood sugar, a condition commonly known as diabetes mellitus. As a quick review, Type 1 diabetes mellitus, which most commonly affects children and adolescents, arises when certain cells of the pancreas known as beta cells are unable to produce enough insulin to maintain normal blood glucose levels.

Can a sulfonylurea cause factitious hypoglycemia?

Ingestion of an oral insulin secretagogue — The first reported case of factitious hypoglycemia related to a sulfonylurea was due to the surreptitious self-administration of chlorpropamide by a patient without diabetes [4]. Inappropriate manipulation of hypoglycemic tablets by a patient with diabetes is another cause of factitious hypoglycemia.