Is piperidine an opioid?

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.

Which analgesic is a phenylpiperidine derivative?

These agents have an important role in many aspects of medicine including anesthesia and pain medicine. After the development of meperidine, fentanyl, which is a second generation synthetic phenylpiperidine series opioid, was synthesized and introduced into clinical anesthesia practice as fentanyl citrate in 1968.

Is meperidine a piperidine?

Meperidine (pethidine) is a phenyl piperidine that is also a strong agonist of μ-opioid receptor.

Is pethidine more potent than morphine?

Pethidine is eight to ten times less potent than morphine, has poor and variable oral absorption, with a short duration of action in the range of 2–3h.

What is the role of phenylpiperidines in medicine?

Phenylpiperidines are a chemical class of drugs with a phenyl moiety directly attached to piperidine. These agents have an important role in many aspects of medicine including anesthesia and pain.

What kind of ring does 4-Phenylpiperidine have?

4-Phenylpiperidine. 4-Phenylpiperidine is a chemical compound. It features a benzene ring bound to a piperidine ring. 4-Phenylpiperidine is the base structure for a variety of opioids, such as pethidine (meperidine), ketobemidone, alvimopan, loperamide, and diphenoxylate .

What kind of antidepressant is phenylpiperazine?

Phenylpiperazine antidepressants. What are Phenylpiperazine antidepressants? Phenylpiperazine antidepressants are drugs that act as serotonin (5-HT2) reuptake inhibitors and serotonin receptor blockers, or just as serotonin receptor blockers.

When was phenylpiperidine published in Nature Chemistry?

Nature Chemistry, doi: 10.1038/s41557-019-0254-5, published online 22 April 2019 The data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated. Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission.