Is kallikrein the same as kinin?

Plasma kallikrein is a serine protease which plays a central role in the contact activation and kinin generation pathways[46].

Who discovered kallikrein?

The term “Kallikrein” was introduced in the 1930s by Werle and colleagues (1, 2) who found high levels of their original isolates in the pancreas (in Greek, the “Kallikreas”). The kallikrein enzymes are now divided into two major categories: plasma kallikrein and tissue kallikrein (3, 4).

What is kinin good for?

The kinin system is involved in many clinical situations including respiratory allergic reactions, septic shock, hypertension and its treatment, hypotensive transfusion reactions, heart diseases, pancreatitis, hereditary and acquired angioedema, Alzheimer disease and liver cirrhosis with ascites1.

Is the kinin system the same as the kallikrein system?

The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research.

How is LMWK produced in the kallikrein system?

It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein. Bradykinin (BK), which acts on the B2 receptor and slightly on B1, is produced when kallikrein releases it from HMWK.

How is bradykinin produced by the kallikrein system?

Bradykinin (BK), which acts on the B2 receptor and slightly on B1, is produced when kallikrein releases it from HMWK. It is a nonapeptide (9 amino acids) with the amino acid sequence Arg–Pro–Pro–Gly–Phe–Ser–Pro–Phe–Arg.

Which is the most important inhibitor of kallikrein?

C1-INH is the most important physiological inhibitor of plasma kallikrein, fXIa and fXIIa. C1-INH also inhibits proteinases of the fibrinolytic, clotting, and kinin pathways. Deficiency of C1-INH permits plasma kallikrein activation, which leads to the production of the vasoactive peptide bradykinin. ^ Seth (1 January 2008).