Is Dicumarol a competitive inhibitor?

Dicumarol is a competitive inhibitor of vitamin K epoxide reductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

Is Dicumarol an anticoagulant?

Dicumarol is a potent and valuable anticoagulant drug. When used properly it appears to prevent intravascular thrombosis in almost all patients.

What is Dicumarol prescribed for?

Introduction. Dicumarol, like warfarin, is a 4-hydroxycoumarin-derived anticoagulant that is used for the treatment of thromboembolic conditions. It was the first of the oral anticoagulants to be isolated and used clinically.

What factors does warfarin inhibit?

COUMADIN and other coumarin anticoagulants act by inhibiting the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S.

How does dicoumarol work as an anticoagulant?

Dicoumarol ( INN) or dicumarol ( USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases . Dicoumarol is a natural chemical substance of combined plant and fungal origin.

How is dicoumarol an antagonist of vitamin K?

These compounds are not antagonists of Vitamin K directly—as they are in pharmaceutical uses—but rather promote depletion of vitamin K in bodily tissues allowing vitamin K’s mechanism of action as a potent medication for dicoumarol toxicity.

What kind of Hay does dicumarol come from?

Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities.

How much is the molecular weight of dicumarol?

Dicumarol PubChem CID 54676038 Synonyms dicumarol dicoumarol 66-76-2 Bishydroxyc Molecular Weight 336.3 g/mol Date s Modify 2021-05-08 Create 2011-12-26