Is chitosan mucoadhesive?

Chitosan is a cationic polysaccharide that exhibits mucoadhesive properties and it has been widely used in the design of mucoadhesive dosage forms. However, its limited mucoadhesive strength and limited water-solubility at neutral and basic pHs are considered as two major drawbacks of its use.

Which one of the following is an example of natural mucoadhesive polymer?

Various natural polymers which can be used in mucoadhesive buccal films are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc.

Why is chitosan mucoadhesive?

Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at pH < 6.5. Reducing the number of amino groups through their half acetylation results in expansion of chitosan’s pH-solubility window up to pH 7.4 but also reduces its capacity to aggregate mucin.

Which polymer can provide maximum Mucoadhesion?

Ionic polymer provides a higher degree of mucoadhesion by interaction of the ionizable functional group with charged component of mucin layer thus promoting a strong adhesiveness.

Is chitosan a sugar?

Chitosan is a sugar that is obtained from the hard outer skeleton of shellfish, including crab, lobster, and shrimp. It is used for medicine.

What is mucoadhesive drug delivery system?

Mucoadhesive drug delivery systems are delivery systems which utilize the property of bioadhesion of certain polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time.

Which mucoadhesive polymer is poor?

At lower concentrations of the polymer chains, there is an inadequate and unstable interaction amongst the poly- mer and the mucosal layer resulting in poor mucoadhesive properties. The contact time amongst the polymer matrix and the mucosal layer can also govern the mucoadhesive property.

Which polymer has excellent Bioadhesion property?

Carbomer is a pH-dependent polymer which stays in solution form at acidic pH but forms a low viscosity gel at alkaline pH. Carbopol offers the advantage of exhibiting excellent mucoadhesive properties in comparison with other polymers (e.g., cellulose derivatives and polyvinyl alcohol) (Davies et al. 1992.

Is chitosan harmful?

When taken by mouth: Chitosan is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. Chitosan might cause mild stomach upset, constipation, or gas. When applied to the skin: Chitosan is POSSIBLY SAFE for most people when applied to the skin for a short time. Chitosan can cause irritation.

Does chitosan raise blood sugar?

Our results showed that high-dose chitosan intake did not affect fasting glucose levels, and there was no evidence that high-dose chitosan had toxic effects or side effects unrelated to treatment; however, excessive dietary fiber may cause gastrointestinal discomfort and affect the absorption of protein, minerals, and …

Which substance is used as mucoadhesive?

Typical examples include poly (acrylic acid) (PAA) and its weakly cross-linked derivatives and sodium carboxymethylcellulose (NaCMC). PAA and NaCMC possess excellent mucoadhesive characteristics due to the formation of strong hydrogen bonding interactions with mucin.

What are characteristics of mucoadhesive system?

Other desired characteristics of a mucoadhesive dosage form include high drug loading capacity, controlled drug release (preferably unidirectional release), good mucoadhesive properties, smooth surface, tastelessness, and convenient application.

Which is the best example of a mucoadhesive polymer?

Among the most studied polymers, univocal evidences of mucoadhesive properties are available for polyacrylates, hyaluronan, chitosan, cellulose derivatives, alginate, pectin and gelatin [14].

How does crosslinked polymeric matrix affect mucoadhesive strength?

Hence highly crosslinked polymeric matrix limits the interpenetration of polymer and mucin chains amongst themselves which in turn results in the decrease in the mucoadhesive strength [34]. Apart from the MW and chain length of the polymer chains, spatial arrangement of the polymer chains may also play an important role.

Which is the optimum molecular weight for mucoadhesion?

First, polymers should present suitable chain flexibility at the pH and ionic strength of the mucus. Within a homogeneous class of polymers, the increase of chain flexibility is expected to favor interpenetration and, therefore, mucoadhesion. At the same time, an optimum molecular weight is likely to exist for mucoadhesion [10].

Which is the result of interaction between mucins and polymers?

Mucoadhesion is the result of multiple steps of interaction between a mucoadhesive polymer and mucins. Even though several theories were developed to comprehensively explain this phenomenon [8], [9], it is preferable to divide the process of mucoadhesive bond formation in two main events [7].