How is rosuvastatin metabolized?

Rosuvastatin is metabolized mainly by CYP2C9 and not extensively metabolized; approximately 10% is recovered as metabolite N-desmethyl rosuvastatin. It is excreted in feces (90%) primarily and the elimination half-life is approximately 19 hours.

What is the mechanism of action of rosuvastatin?

Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

How effective is rosuvastatin 10 mg?

Rosuvastatin 10 mg was significantly more effective at reducing the primary efficacy variable, LDL-C level, than atorvastatin 20 mg after 6 weeks of treatment (mean change -44.6% vs. -42.7%, p < 0.05) (Table 2).

What should be monitored when taking rosuvastatin?

Monitoring Parameters Lipid panel (total cholesterol, HDL, LDL, triglycerides): Lipid profile (fasting or nonfasting) before initiating treatment. Fasting lipid profile should be rechecked 4 to 12 weeks after starting therapy and every 3 to 12 months thereafter.

Can I stop taking rosuvastatin?

You will not get any withdrawal symptoms. But stopping rosuvastatin may cause your cholesterol to rise. This increases your risk of heart attacks and strokes. If you want to stop taking your medicine, it’s important to find another way to lower your cholesterol.

What is the best time to take rosuvastatin?

You can take it at any time as long as you stick to the same time every day. Rosuvastatin will not usually upset your stomach, so you can take it with or without food.

Can I take vitamin D with rosuvastatin?

Interactions between your drugs No interactions were found between rosuvastatin and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Is 10mg of rosuvastatin a lot?

How much you take depends on what you’re taking rosuvastatin for: preventing heart attacks and strokes – the usual dose for adults is 20mg once a day. Sometimes a lower dose may be prescribed. high cholesterol – the usual starting dose for adults and children is 5mg to 10mg once a day.

How long should you take rosuvastatin?

Peak levels of rosuvastatin are seen within three to five hours of oral administration. However, it may take one to two weeks of regular dosing before improvements in your cholesterol level are seen, and up to four weeks before the maximal cholesterol-lowering effects of rosuvastatin are apparent.

Is 10 mg of rosuvastatin a lot?

high cholesterol – the usual starting dose for adults and children is 5mg to 10mg once a day. If needed, your doctor may increase your dose every 4 weeks up to 20mg a day.

Does rosuvastatin cause sleep problems?

The top-selling statins are atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor) and simvastatin (Zocor). How they can cause insomnia: The most common side effect of all types of statins is muscle pain, which can keep people who take them awake at night and unable to rest.