How is calcium involved in bone formation?

Calcium is the major component of the bone, where it is present at more than 99% as calcium-phosphate complexes, and provides the skeleton strength and structure, making the bone a metabolic reservoir to maintain the intra- and extra-cellular calcium pool.

What is the role of the bone in calcium metabolism?

The bones act as a storage site for calcium: The body deposits calcium in the bones when blood levels get too high, and it releases calcium when blood levels drop too low. This process is regulated by PTH, vitamin D, and calcitonin. Cells of the parathyroid gland have plasma membrane receptors for calcium.

Why is calcium metabolism important?

Bone acts as a calcium storage center for deposits and withdrawals as needed by the blood via continual bone remodeling. An important aspect of calcium metabolism is plasma calcium homeostasis, the regulation of calcium ions in the blood plasma within narrow limits.

What are the factors that influence the bone metabolism?

Systemic factors, such as hormonal status, nutrition, physical inactivity, exposure to smoking, alcohol, or particular drugs, as well as a local variation in the load, can influence bone turnover, and consequently, bone mass.

What is the role of calcium metabolism in the body?

Calcium metabolism or calcium homeostasis is the mechanism by which the body maintains adequate calcium levels. Calcium homeostasis regulates calcium flow to and from the bones. Inadequate calcium levels can result in osteoporosis. Calcium release from bone is regulated by parathyroid hormone.

How is the release of calcium from the bone regulated?

Calcium homeostasis regulates calcium flow to and from the bones. Inadequate calcium levels can result in osteoporosis. Calcium release from bone is regulated by parathyroid hormone. Vitamin D is converted to calcidiol (also called calcifediol)

When are calcium and phosphate released to the blood?

Calcium and phosphate are released to blood during bone resorption and deposited into bone during bone formation. Therefore, bone remodeling is an integral part of calcium and phosphate homeostasis.

Who are the authors of calcium and bone metabolism?

Calcium and Bone Metabolism Indices Adv Clin Chem. 2017;82:1-46.doi: 10.1016/bs.acc