Does p53 regulate p21?

p53 down-regulates CHK1 through p21 and the retinoblastoma protein.

What is p53 and p21 genes?

Abstract. In many cell types, p53-mediated growth inhibition is dependent on induction of p21, which is an inhibitor of cyclin-dependent kinases that are required for cell cycle progression. Failure of mutant p53 proteins to transactivate p21 may lead to uncontrolled proliferation.

How does p53 interact with p21?

The p53 protein up-regulates (i.e., increases) the expres- sion of at least two genes, p21 and bax, whose encoded products are able to regulate growth arrest and apoptosis. The p53 protein directly induces the expression of the p21 gene (4).

What is p53 p21 pathway?

The p53/p21 pathway plays a key role in the regulation of cell senescence process of BM-MSCs from SLE patients. These findings could explore the mechanism of cell senescence of BM-MSCs in SLE patients.

What does mutation in p53 lead to?

In most cases, mutant p53 proteins are caused by a single mutation in one of the DNA building blocks, leading to a single amino acid substitution in the p53 protein. In addition to the loss of the normal p53 tumor-suppressing function, the substituted forms of p53 have also gained functions to promote cancer development in a more aggressive way.

What is p53 called?

p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular organisms to suppress cancer.

What is the function of p53 signaling pathway?

P53-mediated cell signal transduction pathway plays an important role in regulating the normal life activities of cells , and it is involved in the regulation of 160 genes . Apoptosis and senescence are the main pathways by which p53 inhibits tumors. Normal p53 can monitor and identify DNA damage points.