Does daptomycin cause muscle pain?

If you have unexplained muscle pain, tenderness, or weakness while receiving this medicine, check with your doctor right away. This medicine may cause serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heart.

Can daptomycin cause neuropathy?

Rare cases of peripheral neuropathy have been observed in patients receiving daptomycin. Monitoring for new-onset or worsening neuropathy is recommended.

What are the most common side effects of daptomycin?

More common

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
• difficulty having a bowel movement.

Can daptomycin cause rhabdomyolysis?

Rhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing.

Is daptomycin a strong antibiotic?

Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises.

Does daptomycin affect blood pressure?

rash, itching, sweating; trouble sleeping; sore throat; or. increased blood pressure.

When should you not take daptomycin?

1.0 Daptomycin should not be used to treat pneumonia. 2.0 Daptomycin should not be used for empiric therapy of non-life-threatening infections where there is little evidence that MRSA or VRE are infecting or colonizing microorganisms.

How long should I take daptomycin?

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Some infections must be treated for up to 6 weeks. Skipping doses can increase your risk of infection that is resistant to medication. Daptomycin will not treat a viral infection such as the flu or a common cold.

When should daptomycin be discontinued?

Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.

How long do you take daptomycin?

Daptomycin may be injected for 2 minutes (in adults only) or it may be given slowly, so the needle will have to remain in place for up to 60 minutes. To help clear up your infection completely, keep using daptomycin for the full time of treatment, even if you begin to feel better after a few days.

How long does it take for daptomycin to work?

This medicine may be injected for 2 minutes (in adults only) or it may be given slowly, so the needle will have to remain in place for up to 60 minutes. To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days.

Is daptomycin stronger than vancomycin?

Three recent cohort studies comparing daptomycin and vancomycin for bloodstream infections (BSIs) due to MRSA with a high vancomycin MIC demonstrated that daptomycin was associated with a better outcome, both in terms of rates of clinical success and mortality, compared to vancomycin [16-18].

What are the side effects of daptomycin injections?

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site difficulty having a bowel movement

What was the CPK of a patient on daptomycin?

Cultures of blood and urine samples at the time of her transfer showed VRE with intermediate resistance to linezolid. The patient, who was neutropenic at this time, was started on IV daptomycin 550 mg (6 mg/kg) every 24 hours. The patient’s baseline CPK was 108 units/L and serum creatinine level was 0.8 mg/dL.

How much Daptomycin is in a single dose?

Daptomycin for Injection is supplied in single -dose vials, each containing 350 mg daptomycin as a sterile, lyophilized powder. The contents of a Daptomycin for Injection vial should be reconstituted, using aseptic technique, to 50 mg per mL as follows: 1. To minimize foaming, AVOID vigorous agitation or shaking of the vial during or after

When to discontinue daptomycin for myopathy?

(5.1) Myopathy and rhabdomyolysis: Monitor CPK levels and follow muscle pain or weakness; if elevated CPK or myopathy occurs, consider discontinuation of daptomycin. (5.2) Eosinophilic pneumonia: Discontinue daptomycin and consider treatment