Are Dohle bodies normal in cats?

hema33-Dohle bodies. The presence of Döhle bodies in mature and immature neutrophils on a blood smear can be normal if they are present only in small numbers. They are also normally more abundant in cats and horses.

What are Dohle bodies?

Döhle bodies are small, round or oval, pale blue–grey structures usually found at the periphery of the neutrophil. They consist of ribosomes and endoplasmic reticulum.

What is toxic granulation associated with?

Toxic granulation can be associated with infection and inflammation. Increased granulation of neutrophils may also be present in some genetic disorders, following treatment with myeloid growth factors (G-CSF or GM-CSF), in a marrow responding to myelosuppressive therapy, with pregnancy, and in uremia.

Where are Dohle bodies seen?

Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1-3 μm in diameter. Not much is known about their formation, but they are thought to be remnants of the rough endoplasmic reticulum.

Why are Dohle bodies found in cats and horses?

They are also normally more abundant in cats and horses. Döhle bodies are intra-cytoplasmic structures composed of agglutinated ribosomes; they will increase in number with inflammation and increased granulocytopoiesis. If there are many neutrophils in the bloodstream containing Döhle bodies, these can be referred to as toxic neutrophils.

What kind of hyperesthesia does a cat have?

Feline hyperesthesia is also called twitch-skin syndrome. It is a rare disorder in cats where the cat has episodes of frantic biting or licking of the back half of their body.

Where are the Dohle bodies located in the body?

Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1-3 µm in diameter. Not much is known about their formation, but they are thought to be remnants of the rough endoplasmic reticulum. They are named after German pathologist, Karl Gottfried Paul Döhle (1855-1928).

Why do Dohle bodies not always indicate toxic change?

Thus, Döhle bodies alone do not always indicate toxic change. Cytoplasmic vacuolation: These are indistinct vacuoles in the cytoplasm, giving it a frothy appearance and is due to degranulation of lysosomes.