Why are glucocorticoids contraindicated in osteoporosis?

Glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor I expression. The stimulation of bone resorption is likely responsible for the initial bone loss after glucocorticoid exposure.

How do glucocorticoids cause osteoporosis?

Corticosteroids tend to both reduce the body’s ability to absorb calcium and increase how fast bone is broken down. The more of these drugs you take and the longer you take them, the greater your risk of developing osteoporosis.

How do you manage glucocorticoid-induced osteoporosis?

Bisphosphonates are the front-line choice for prevention of fracture in glucocorticoid-treated patients, with teriparatide as the second-line option; calcium and vitamin D supplements should be co-prescribed in the majority of individuals.

Why are corticosteroids associated with osteoporosis?

Steroids have major effects on how the body uses calcium and vitamin D to build bones. Steroids can lead to bone loss, osteoporosis, and broken bones. When steroid medications are used in high doses, bone loss can happen rapidly. Not all people who take steroid medications lose bone or lose bone at the same rate.

What are the guidelines for osteoporosis?

New osteoporosis guidelines recommend that all postmenopausal women aged 50 and older be evaluated for osteoporosis risk. Such evaluation should include a detailed history, physical exam and clinical fracture risk assessment. The guidelines were developed by the American Association of Clinical Endocrinologists

Who criteria for osteoporosis?

The World Health Organization (WHO) developed criteria for diagnosing osteoporosis (a bone-thinning condition that can result in bone fracture) based on a measurement of bone mineral density called a T-score. These scores are best determined by dual-energy x-ray absorptiometry ( DXA ). A T-score of -2.5 or lower marks the threshold for osteoporosis.

What is steroid induced osteoporosis?

Steroid-induced osteoporosis is osteoporosis arising due to use of glucocorticoids (steroid hormones) – analogous to Cushing’s syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake.