Which lipid lowering agents should not be combined?

Lovastatin and simvastatin should not be combined with the following drugs: erythromycin. ketoconazole (Nizoral, Extina, Xolegel, Kuric) itraconazole.

What medications interact with rosuvastatin?

What Other Drugs Interact with Rosuvastatin?

• atazanavir.
• clarithromycin.
• colchicine.
• cyclosporine.
• eltrombopag.
• fenofibrate.
• fenofibrate micronized.
• fenofibric acid.

Which statin has the lowest risk of drug interactions?

As fluvastatin, pravastatin, rosuvastatin are primarily metabolized by CYP2C9, they are less subject to drug interaction than other statins.

What is a contraindication of cholesterol lowering medications?

Statins are contraindicated for use by patients with active hepatic disease or unexplained persistent elevations in aminotransferase levels. Statins are contraindicated during pregnancy and while breastfeeding because of the effects on the cholesterol pathway.

What supplements should not be taken with rosuvastatin?

A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption. People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

What is the best cholesterol medication with the least side effects?

In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications.

Which statin is least likely to cause muscle pain?

Even though all statins look similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin and pitavastatin are the least likely.

What is the safest drug to take for high cholesterol?

Still, all in all, the statins are the safest and best tolerated of all cholesterol-lowering medications.

Can I refuse statins?

We know that for patients at high risk, statins can do this — and potentially save lives. Before you refuse to take a statin or stop taking a statin, consult your doctor. He or she can explain why you may benefit from the drug or help you find a different statin if you experience side effects.

Are there any drug interactions with lipid lowering drugs?

Lipid-lowering drugs, especially 3-hydroxy-3-methylglutaryl-coenzyme A inhibitors (statins), are widely used in the treatment and prevention of atherosclerotic disease. The benefits of statins are well documented. However, lipid-lowering drugs may cause myopathy, even rhabdomyolysis, the risk of whi …

How does Pi affect the metabolism of a statin?

The degree to which statin metabolism is affected by PIs varies according to the statin as well as the specific PI. Unfortunately, many specific interactions have not been studied. In general, the potential for inhibition of statin metabolism is as follows: simvastatin and lovastatin > atorvastatin and rosuvastatin >> pravastatin.

Can a lipid lowering drug cause myopathy?

However, lipid-lowering drugs may cause myopathy, even rhabdomyolysis, the risk of which is increased by certain interactions.

Which is the most effective lipid lowering agent?

The most effective agents for reducing LDL levels are the HMG-CoA reductase inhibitors (“statins”) , because they block cholesterol synthesis at its rate limiting step.