What is insulin-independent glucose transporter?

The glucose transport proteins (GLUT1 and GLUT4) facilitate glucose transport into insulin-sensitive cells. GLUT1 is insulin-independent and is widely distributed in different tissues. Thus, insulin-independent glucose transport through GLUT1 can meet the basal needs of the muscle cell.

Does insulin stimulate glucose transport?

The effect of insulin to acutely stimulate glucose uptake into muscle and adipose tissue is essential for normal glucose homeostasis. The GLUT4 glucose transporter is a major mediator of this action, and insulin recruits GLUT4 from an intracellular pool to the plasma membrane.

What is the role of insulin in glucose transport?

1. Insulin facilitates entry of glucose into muscle, adipose and several other tissues. The only mechanism by which cells can take up glucose is by facilitated diffusion through a family of hexose transporters.

What is the transport system that transports glucose into a cell?

Glucose transporter (GLUT) is a facilitative transport protein involved in glucose translocation across the cell membrane.

Is GLUT2 insulin independent?

GLUT2 is insulin independent (Liver and pancreas), GLUT4 is insulin dependent (on muscle, adipose , heart). GLUT2 has a higher Km and so transport is not maximally active at low concentrations.

Which tissues are insulin dependent for glucose uptake?

In brief, Skeletal muscle accounts for approximately 70% of insulin mediated glucose uptake. Adipose tissue accounts for about 10% of insulin dependent glucose uptake. While intracellular glucose uptake in the liver is not insulin dependent, insulin does modulate key metabolic processes in the liver through signalling cascades.

What regulates insulin levels in blood?

Chromium is an essential mineral that appears to have a beneficial role in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolism. Chromium is an important factor for enhancing insulin activity. Studies show that people with type 2 diabetes have lower blood levels of chromium than those without the disease.

Does glucose uptake in muscles without insulin?

An increase in muscle transport and uptake of glucose during contractions does not require the presence of insulin. Furthermore, glucose transport in contracting muscle may only increase if glycogen is depleted.