What is cyclizine made of?

Each tablet contains 50 mg of the active ingredient, cyclizine hydrochloride. The other ingredients include: lactose, potato starch, acacia and magnesium stearate. Cyclizine Hydrochloride Tablets are white with a single score line and the marking “T4A” on the same side. They are available in bottles of 100 tablets.

Is cyclizine an anticholinergic?

Cyclizine is a histamine H1 receptor antagonist of the piperazine class which is characterised by a low incidence of drowsiness. It possesses anticholinergic and antiemetic properties. The exact mechanism by which cyclizine can prevent or suppress both nausea and vomiting from various causes is unknown.

What type of drug is cyclizine?

Cyclizine is a type of drowsy (sedating) antihistamine, as it can make you feel sleepy. There are other drowsy antihistamines that can help with feeling or being sick, such as promethazine and cinnarizine.

Is cyclizine a phenothiazine?

Examples of anti-histamines include dimenhydrinate, cinnarizine, cyclizine, buclizine, and meclizine. The most common phenothiazine used is promethazine, which blocks both dopamine and histamine receptors.

What is the role of cyclizine in the human body?

Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as an antiemetic, a cholinergic antagonist, a central nervous system depressant, a local anaesthetic and a H1-receptor antagonist.

What was the trade name for cyclizine hydrochloride?

Cyclizine was quickly clinically found as a potent and long-acting antiemetic. The company named the substance – or more precisely cyclizine’s hydrochloride form which it usually appears in – “marezine hydrochloride” and started to sell it in the United States under trade name Marezine. Selling was begun in France under trade name Marzine in 1965.

How is cyclizine prepared as a hydrobromide salt?

Cyclizine exerts a central anticholinergic ( antimuscarinic) action. Cyclizine may be prepared by the Eschweiler–Clarke methylation of diphenylmethylpiperazine or by reaction of benzhydryl bromide with 1-methylpiperazine in acetonitrile to form the hydrobromide salt of the drug.

What kind of forms are available for cyclizine?

Forms available from special-order manufacturers include: oral suspension, oral solution, suppository Tablet, Solution for injection