What is an example of a drug-drug interaction?

A drug-drug reaction is when there’s an interaction between two or more prescription drugs. One example is the interaction between warfarin (Coumadin), an anticoagulant (blood thinner), and fluconazole (Diflucan), an antifungal medication.

What is a pharmacodynamic drug interactions?

Pharmacodynamic drug-drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.

At what 3 pharmacodynamic processes can drug-drug interactions occur?

The pharmacodynamic interactions of drug-on-drug can be divided into three broad groups: interference with drug effects on receptor function, interference with a physiological control process, and additive or opposing physiological effects. To elaborate on these is the objective of this chapter.

Which is an example of a pharmacodynamic interaction?

Pharmacodynamic interactions. The term “pharmacodynamic interactions” refers to interactions in which drugs influence each other’s effects directly. As a rule, for example, sedatives can potentiate each other. The same is true of alcohol, which can potentiate the sedative effects of many drugs.

Which is an example of a drug-food interaction?

Drug-Food interactions  A drug-food interaction happens when the food you eat affects the ingredients in a medicine you are taking so the medicine cannot work the way it should. 1. Bisphosphonates+ Any drug Reduced effectiveness of drug` 2. Benzodiazepines + grapefruit Inhabit enzymes involved in drug metabolism 3.

Why do we need to know about drug interactions?

The systematic knowledge of drug interaction, in particular on the level of absorption, elimination, transport and drug metabolism may help to prevent adverse effects. Predicting pharmacodynamic interactions often demands a deeper understanding of the mechanisms of effect. Electronic prescribing systems are helpful.

Where do pharmacokinetic interactions occur in the body?

Pharmacokinetic interactions occur at the levels of absorption (e.g., levothyroxine and neutralizing antacids), elimination (e.g., digoxin and macrolides), and metabolism, as in the competition for cytochrome P450 enzymes (e.g., SSRIs and certain beta-blockers).