What happens to MCHC in megaloblastic anemia?

Normal mean corpuscular hemoglobin concentration (MCHC, 32–36 g/dL) Decreased reticulocyte count due to destruction of fragile and abnormal megaloblastic erythroid precursor. The platelet count may be reduced.

Why does MCHC increase in megaloblastic anemia?

Defects in nuclear maturation, as seen in megaloblastic anemias due to folate or B12 deficiency, result in large oval erythrocytes (macroovalocytes) with a normal hemoglobin content. The MCV and MCH are increased, while the MCHC remains normal.

How does MCH increase in megaloblastic anemia?

The mean cell hemoglobin (MCH) is elevated by the increased volume of the cells, but the mean cell hemoglobin concentration (MCHC) is usually within the reference interval because hemoglobin production is unaffected. The red blood cell distribution width (RDW) is also elevated.

What is the difference between megaloblastic anemia and non megaloblastic anemia?

Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syndrome (MDS), liver dysfunction, alcoholism, hypothyroidism, certain drugs, and by less commonly inherited disorders of …

What causes megaloblastic anemia and nonmegaloblastic macrocytic anemia?

Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syndrome (MDS), liver dysfunction, alcoholism, hypothyroidism, certain drugs, and by less commonly inherited disorders of DNAsynthesis.

What are the causes of increased MCV and MCh?

Causes Of Increased MCV – Megaloblastic Anemia, Chronic Alcoholism, Liver Disease, Normal Pregnancy, Reticulocytosis, In Newborns, etc. Causes Of Decreased MCV – Iron deficiency anemia, Thalassemia, Hemolytic Anemia etc. Before proceeding to the other parameters of Red Cell indices that is MCH and MCHC, let’s briefly learn about hemoglobin

Is the reticulocyte count normal for megaloblastic anemia?

The reticulocyte count is normal or low. Cellularity: Moderately to markedly hypercellular. M:E ratio: Due to marked erythroid hyperplasia, M:E ratio is reversed ranging from 1:1 to 1:6 (normal 2:1 to 4:1). Erythropoiesis: Megaloblastic type.

Is there a cure for megaloblastic anemia?

However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause—eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.