What does TAP1 do?

The TAP1 gene provides instructions for making a protein that plays an important role in the immune system. The TAP1 protein assembles with another protein called TAP2 (produced from the TAP2 gene) to form a protein complex called transporter associated with antigen processing (TAP) complex.

What is TAP1 and TAP2?

The TAP1 and TAP2 proteins form a functional heterodimeric complex in the membrane of the endoplasmic reticulum that is responsible for ATP-dependent translocation of short peptides (8–16 residues) from the cytosol into the lumen of the endoplasmic reticulum (Reits et al., 2000b).

What is the function of Tapasin?

Tapasin is a MHC class I antigen-processing molecule present in the lumen of the endoplasmic reticulum. It plays an important role in the maturation of MHC class I molecules in the ER lumen.

What is TAP gene?

The transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette transporter family that specializes in delivering cytosolic peptides to class I molecules in the endoplasmic reticulum. The TAP is a major target of genetic alteration in tumours and disruption by viral inhibitors.

Why is the TAP1 gene important to the immune system?

The TAP1 gene provides instructions for making a protein that plays an important role in the immune system. The TAP1 protein assembles with another protein called TAP2 (produced from the TAP2 gene) to form a protein complex called transporter associated with antigen processing (TAP) complex.

How does TAP1 function as a peptide transporter?

In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed: 25656091, PubMed: 25377891 ). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed: 25377891 ).

Which is a member of the MDR / TAP subfamily?

This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble.

Which is the best protein powder for lactose intolerant?

This egg white protein powder is free of dairy, making it a good choice for people who have a lactose intolerance. It’s also gluten-free and is extracted using a process that makes it easily digestible. Additionally, the powder is free of GMOs, antibiotics, and hormones.