What does SR protein stand for?

RNA splicing
SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are “S” and “R” respectively.

What are RNA connectors?

Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.

What is SC35?

SC35 belongs to the family of SR proteins that regulate alternative splicing in a concentration-dependent manner in vitro and in vivo. In vitro splicing experiments performed with recombinant SR proteins demonstrate that SC35, but not ASF/SF2 or 9G8, specifically activates these alternative splicing events.

What is the function of splicing factor?

A splicing factor is a protein involved in the removal of introns from strings of messenger RNA, so that the exons can bind together; the process takes place in particles known as spliceosomes. Genes are progressively switched off as we age, and splicing factors can reverse this trend.

What do SR proteins do in the nucleus?

SR proteins are a large family of nuclear phosphoproteins required for constitutive and alternative splicing. A subset of SR proteins is known to shuttle between the nucleus and cytoplasm, suggesting that these proteins play important cytoplasmic roles in mRNA metabolism.

How many proteins are in the SR protein family?

SR proteins comprise a family of eight proteins with a modular organization and high conservation among metazoans.

Why are SR proteins important in alternative splicing?

SR proteins are important for selecting splice sites for alternative splicing. SR proteins recognize intron and exon enhancers and silencers.

What is the role of SR-B1 in cholesterol?

The scavenger receptor, class B type 1 (SR-B1), is a multiligand membrane receptor protein that functions as a physiologically relevant high-density lipoprotein (HDL) receptor whose primary role is to mediate selective uptake or influx of HDL-derived cholesteryl esters into cells and tissues.