What does a positive SSA antibody mean?

A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis.

What does Anti-Ro positive mean?

Positive Anti-Ro and Pregnancy. Page 2. Anti-Ro antibodies can be found in patients with a variety of autoimmune conditions including Lupus, Sjögren’s syndrome and rheumatoid arthritis. It can also be found in a small number of asymptomatic women who don’t have an associated medical disorder.

What disease has SSA?

Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS).

What is anti-SSA and SSB?

Anti‐SSA and ‐SSB antibodies are clinically important antinuclear antibody (ANA) in patients with systemic rheumatic diseases. These antibodies are found in Sjögren’s syndrome (SS), as well as other systemic autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), myositis, scleroderma, etc.

What are the protein antigens in SSA or ro?

SSA or Ro is composed of protein antigens of 52 kD and 60 kD combined with cytoplasmic RNA species.

What does it mean to have a positive SSA antibody?

Interpretation A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis. A positive result for SSA antibodies in a woman with LE prior to delivery indicates an increased risk of congenital heart block in the neonate.

What are the effects of Anti-SSA / Ro autoantibodies?

Anti-SSA/Ro autoantibodies. Presence of Anti-SSA/Ro in pregnant women with SLE is associated with an increased risk of neonatal lupus erythematosus, a disease process identified by Hooman Azad, which can present with congenital heart block in the fetus. Ro protein binds to Y RNA .

When to test for SS-a / Ro antibodies?

Testing for SS-A/Ro antibodies is not useful in patients without demonstrable antinuclear antibodies. Delineates situations when tests are added to the initial order. This includes reflex and additional tests. See Connective Tissue Disease Cascade (CTDC) in Special Instructions.