What does a mutase do?

A mutase is an enzyme of the isomerase class that catalyzes the movement of a functional group from one position to another within the same molecule. In other words, mutases catalyze intramolecular group transfers.

What does an Epimerase enzyme do?

About Epimerase: An isomerase enzyme, epimerase catalyzes the stereochemistry inversion within biological chemicals. They configure an asymmetric carbon atom from a substrate which has more than one center for asymmetry and forms interconverting epimers.

What is the difference between a mutase and an isomerase?

The key difference between isomerase and mutase enzyme is that isomerase is a class of enzymes that can convert an isomer to another isomer form of the same molecule, whereas mutase enzyme is a type of isomerase enzyme that can change the position of a functional group in a molecule without changing the chemical …

What does Methylmalonyl CoA Mutase do?

Methylmalonyl-CoA mutase (MCM), mitochondrial, also known as methylmalonyl-CoA isomerase, is a protein that in humans is encoded by the MUT gene. This vitamin B12-dependent enzyme catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA in humans.

How are Epimerases and racemases used in biology?

Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules. Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry.

What are the effects of methylmalonyl-CoA mutase?

The pathway involves the formation of propionyl-CoA and its conversion to methylmalonyl-CoA prior to the formation of succinyl-CoA. Affected newborns are characterized by recurrent vomiting, hepatomegaly, and developmental retardation owing to accumulation of methylmalonic acid.

What is the role of epimerase in the metabolic pathway?

Epimierases function as part of crucial metabolic pathways. This does include the Leloir pathway which is where the conversion from galactose to glucose-1 phosphate occurs. Furthermore, bacterial epimerase are also involved with the creation of complex carbohydrate polymers.

How does epimerase remove protons from UDP-galactose?

Epimerase Mechanism One particular mechanism involves inverting the configuration of a 4’hydroxl group of UDP-galactose. This is completed through a series of four steps. Once bound the conserved tyrosine residue within the active site, then removes a proton from the 4’ hydroxyl group.