What causes pure red cell aplasia?

Acquired Pure Red Cell Aplasia is thought to be an autoimmune disorder possibly caused either by a tumor of the thymus gland, certain drugs or a viral infection. It is one of a group of bone marrow failure syndromes.

How do you treat pure red cell aplasia blood?

Corticosteroids: Corticosteroid treatment in the form of oral prednisone is considered the mainstay of therapy for pure red cell aplasia. A corticosteroid helps the bone marrow make more red blood cells.

Is pure red cell aplasia cancer?

The “pure” red cell aplasia, Diamond Blackfan anemia, felt by many to be the “sine qua non” of pediatric hematology, is one of a rare group of inherited bone marrow failure syndromes (IBMFS) distinguished by the variable presence of congenital anomalies and a predisposition to cancer.

Is there such a thing as pure red cell aplasia?

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent.

What kind of resection is done for thymoma?

Extended thymectomy (n=4) and thymectomy (n=4) were performed for thymoma. Regarding the WHO classification of thymoma, the subtypes were type B2 or B3 in seven patients, and the stage of thymoma was advanced in seven patients. Complete resection was achieved macroscopically in only five patients.

What kind of autoimmune disorder is primary acquired PRCA?

Primary acquired PRCA is an autoimmune disorder in which an immune mechanism interrupts erythroid differentiation. This may be mediated by an autoantibody or by another immunologic process.

Which is the most common blood disorder associated with PRCA?

The lymphoproliferative disorders most frequently associated with PRCA are chronic lymphocytic leukemia and large granular lymphocyte (LGL) leukemia, 15, 16 although it has been reported with Hodgkin and non-Hodgkin lymphoma, as well as Waldenstrom macroglobulinemia, as outlined in Table 1.