What are hepatic enzyme inducers?

Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes.

What are the drugs that inhibit or induce the hepatic enzymes?

Among the drugs metabolised are sedatives such as midazolam, triazolam, and diazepam, the antidepressives amitriptyline and imipramine, the anti-arryhthmics amiodarone, quinidine, propafenone and disopyramide, the antihistamines terfenadine, astemizole and loratidine, calcium channel antagonists such as diltiazem and …

What drugs are enzyme inducers?

Enzyme-inducing antiepileptic drugs

• Carbamazepine.
• Eslicarbazepine acetate.
• Oxcarbazepine.
• Perampanel (at a dose of 12 mg daily or more).
• Phenobarbital.
• Phenytoin.
• Primidone.
• Rufinamide.

What are examples of enzyme inducers?

Examples of enzyme inducers include aminoglutethimide, barbiturates, carbamazepine, glutethimide, griseofulvin, phenytoin, primidone, rifabutin, rifampin, and troglitazone. Some drugs, such as ritonavir, may act as either an enzyme inhibitor or an enzyme inducer, depending on the situation.

What makes a drug an enzyme inducer or inhibitor?

Enzyme Inducers are drugs which increase the metabolism of other drugs in the body. As you can see most of the antiepileptic drugs cause enzyme Induction, just like inducing an episode of epilepsy! What are the Enzyme Inhibitors? Enzyme inhibitors are drugs which decrease the metabolism of drugs by inhibiting microsomal enzymes.

What causes enzyme induction and inhibition in the liver?

Atypical metabolic ratios may be caused by either genetic factors, i.e. polymorphisms in those genes expressing specific DMEs, or alternatively by extrinsic factors, e.g. by agents causing enzyme induction or inhibition. Table 1. Enzymes, substrates and probe drugs.

How are antiepileptic drugs similar to enzyme inducers?

As you can see most of the antiepileptic drugs cause enzyme Induction, just like inducing an episode of epilepsy! What are the Enzyme Inhibitors? Enzyme inhibitors are drugs which decrease the metabolism of drugs by inhibiting microsomal enzymes. Another mnemonic for enzyme Inhibitors is:

How are inducers and inhibitors used in metabolism?

The inhibitors listed here can be used together with other information, such as metabolic profiles obtained from single enzyme expression systems. Table 1-3. Examples of in vitro inducers for P450-mediated metabolism (9/26/2016)