Is valacyclovir water soluble?

Solubility: The solubility of valacyclovir in water is 174 mg/mL. At the highest dose strength, the BCS volume would be 5.75 mL (1000 mg ÷ 174 mg/mL).

What drugs interact with Valtrex?

Most frequently checked interactions

• Adderall (amphetamine / dextroamphetamine)
• Cymbalta (duloxetine)
• gabapentin.
• ibuprofen.
• levothyroxine.
• Lexapro (escitalopram)
• lisinopril.
• Lyrica (pregabalin)

How is valacyclovir metabolized?

After absorption, valacyclovir is converted to acyclovir by the liver, which is metabolized intracellularly in viral infected cells and is excreted largely unchanged by the kidneys.

Can Valtrex be used for other things?

In adults, it is used to treat shingles (caused by herpes zoster) and cold sores around the mouth. Valacyclovir is also used to treat outbreaks of genital herpes.

What class of drug is valacyclovir?

Valacyclovir is the L-valine ester of aciclovir. It is a member of the purine (guanine) nucleoside analog drug class 10. This class of drugs forms an important part of hepatitis, HIV, and cytomegalovirus drug regimens 4. One major use of valacyclovir is the treatment of genital herpes episodes or outbreaks.

What enzyme converts valacyclovir to acyclovir?

Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes.

Are you contagious on Valtrex?

It is important to keep in mind that Valtrex is not a cure for genital herpes, and there may still be contagious lesions or shedding that occur while taking the medication. While daily treatment can reduce the risk of transmission, it isn’t 100% guaranteed that you won’t become infected.

Do antivirals weaken immune system?

The inhibitory effects of antivirals on immune cells may contribute to the immune deterioration observed in patients following prolonged use of the drugs.

Is Valtrex hard on your kidneys?

Valtrex can be harmful to the kidneys, and these effects are increased when it is used together with other medicines that can harm the kidneys. Tell your doctor about all other medications you are using. You may need dose adjustments or special tests when taking certain medications together with Valtrex.

Is Valtrex hard on liver?

In short, valacyclovir is not linked to dangerously high liver enzyme levels, and the drug is not considered to be heavily liver toxic. If you have normal liver function, there is little need to be concerned about liver damage when taking valacyclovir for cold sores or genital herpes.

Does Valtrex stop the spread of shingles?

Valtrex is an antiviral medication that can help stop the shingles virus from replicating. The symptoms of shingles can last anywhere between 3 and 5 weeks. Valtrex doesn’t cure shingles, but it helps to keep the virus from multiplying.

Does Valtrex make you gain weight?

Valtrex (valacyclovir) and other antiviral medications can only treat the symptoms associated with herpes infections and shorten outbreaks. Does Valtrex (valacyclovir) make you gain weight? Weight changes are not commonly reported with the use of Valtrex (valacyclovir).

What kind of infections can Valtrex be used for?

Valtrex is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults.

Are there any side effects from taking Valtrex?

Valtrex can harm your kidneys. This risk may increase when you also use certain other medicines, including: antivirals, chemotherapy, certain antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Advil, and Aleve).

What are the ingredients in Valtrex caplets 500 mg?

Ingredients and Preparation per USP─NF: VALTREX Caplets 500 mg, cherry flavor, and Suspension Structured Vehicle USP─NF (SSV). Valacyclovir oral suspension (25 mg/mL or 50 mg/mL) should be prepared in lots of 100 mL.

Is there an oral suspension of Valtrex for children?

Valacyclovir oral suspension (25 mg/mL or 50 mg/mL) may be prepared extemporaneously from 500-mg Valtrex Caplets for use in pediatric patients for whom a solid dosage form is not appropriate [see Dosage and Administration (2.3)].