Is PSA a kallikrein?

The introduction of testing for prostate-specific antigen (PSA), a member of the fifteen-gene family of kallikrein-related peptidases and also known as kallikrein-related peptidase 3 (KLK3), in blood has revolutionized both the detection and management of prostate cancer.

What is the function of kallikrein?

The function of plasma kallikrein includes its participation in the process of blood clotting and fibrinolysis and, through the release of bradykinin, in the regulation of vascular tone and inflammatory reactions (7).

What is a good number for prostate cancer?

0 to 2.5 ng/mL is considered safe. 2.6 to 4 ng/mL is safe in most men but talk with your doctor about other risk factors. 4.0 to 10.0 ng/mL is suspicious and might suggest the possibility of prostate cancer.

Is PSA a good predictor of metastatic prostate cancer?

Serum PSA has been reported to be the single most useful predictor of metastasis detected on radionuclide scanning in patients with prostate cancer. [8–10] Previous studies have suggested a serum PSA of more than 10 ng/ml as an appropriate cut-off for consideration of BS in such patients.

How is KLK2 used to treat prostate cancer?

Further mechanism dissection shows that KLK2 may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of PCa formation. Together, these results suggested KLK2 might become a new therapeutic target to battle the CRPC and KLK2-siRNA may be developed as an alternative approach to suppress PCa growth.

What is the role of HK2 in prostate cancer?

Recombinant hK2 activates ERK1/2 signaling of prostate cancer cell lines, which express both PAR1 and PAR2. The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression.

Where is Kallikrein related peptidase 2 located on chromosome 19?

KLK2 kallikrein related peptidase 2 [ (human)] Summary. This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19.

When to take the 4kscore prostate cancer test?

Test Code Test Name 2014059 4Kscore (Prostate-Specific Kallikrein) The 4Kscore Test is recommended for men concerned with their risk for high-grade, aggressive prostate cancer and is especially useful when considering a prostate biopsy.