Is CIPA a mental illness?

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature, and prevents a person from sweating. Cognitive disorders are commonly coincident.

What is CIPA and why is it fatal?

In fact, half of CIPA deaths are due to overheating because of the person’s inability to produce sweat. This causes hyperthermia, or extremely elevated body temperature, which then leads to death. Excessive self-mutilation can also lead to death in some cases.

Is CIPA a disability?

Intellectual disability. Most individuals with NTRK1-CIPA have varying degrees of intellectual disability and show characteristic behaviors [Indo 2002, Indo 2018]. Affected individuals show defects in conceptual thinking, abstract reasoning, and social behavior, as well as moderate to severe emotional disturbance.

What do you need to know about CIPA disease?

CIPA Disease: When a Person Can’t Feel Pain 1 Symptoms.CIPA disease is present at birth and makes people unable to sense pain or temperature and unable to sweat. 2 Diagnosis.There are not simple X-ray tests or blood tests that can identify CIPA. 3 Primary Causes.CIPA is a hereditary disease. 4 Treatment. 5 Expectations.

What’s the name of the gene that causes CIPA?

The abnormal gene responsible for CIPA, human TRKA (NTRK1), is a gene that directs the body to develop mature nerves. It specifically promotes nerve growth by encoding a receptor called tyrosine kinase (RTK,), which is autophosphorylated in response to nerve growth factor (NGF).

What causes congenital insensitivity to pain ( CIPA )?

Human TRKA (NTRK1) encodes the receptor tyrosine kinases (RTKs) for nerve growth factor (NGF) and is the gene responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive disorder characterized by a lack of pain sensation and anhidrosis.

What kind of neuropathy is CIPA type IV?

It is part of the hereditary sensory and autonomic neuropathy diseases (HSAN); speciÞcally it is known as HSAN type IV. CIPA is characterized by the absence of reaction to noxious stimuli, the inability to sweat, hyperpyrexia, mild retardation, and self- mutilating behavior.