Is aripiprazole a CYP3A4 inhibitor?

Ritonavir is a known strong inhibitor of CYP3A4 and a moderate inhibitor of CYP2D6 (Table 1), and, therefore, may decrease the metabolism of aripiprazole, a CYP3A4 and CYP2D6 substrate….Table 1.

What are the contraindications of aripiprazole?

Who should not take ARIPIPRAZOLE?

• diabetes.
• overweight.
• very low levels of granulocytes, a type of white blood cell.
• low levels of white blood cells.
• low levels of a type of white blood cell called neutrophils.
• confusion.
• suicidal thoughts.
• Alzheimer’s disease.

What is the mechanism of action of aripiprazole?

Aripiprazole is a partial agonist at D2 receptors. It may act as an antipsychotic by: Lowering dopaminergic neurotransmission in the mesolimbic pathway. Enhancing dopaminergic activity in the mesocortical pathway.

What are the pharmacodynamics of aripiprazole?

Aripiprazole is the first approved atypical antipsychotic with a mechanism of action that exerts a partial agonism with high affinity at Dopamin D2- and Serotonin-5-HT1A-receptors as well as an antagonism at Serotonin-5-HT2A-receptors.

Will I gain weight on Abilify?

Abilify is also associated with metabolism problems. This can lead to weight gain and dangerously high blood sugar levels.

Does aripiprazole make you high?

Dopamine agonists such as aripiprazole activate dopamine receptors in the brain, literally opening up those pathways. Among the resulting side effects are euphoria, increased orgasmic activity and pathological addictions that include compulsive gambling, shopping, binge eating and sexual behavior.

Is 10 mg of aripiprazole a lot?

ABILIFY has been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day, when administered as the tablet formulation; however, doses higher than 10 or 15 mg/day were not more effective than 10 or 15 mg/day.

Does aripiprazole lower dopamine?

To summarize, aripiprazole, as a dopamine partial agonist, acts as a modulator of dopamine effects. When present, it diminishes the effects of both dopamine excess (by decreasing dopamine action when there is too much of it) and deficit (by increasing dopamine action when there is too little of it).

What does aripiprazole do to your brain?

Aripiprazole is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Aripiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior.

Can Abilify give you energy?

Aripiprazole can make you tired. Somnolence, or a strong urge to sleep, is more common in children. The effects may be higher with bigger doses. But aripiprazole may cause less somnolence than similar drugs.

How fast do you gain weight on Abilify?

In clinical trials of adolescent patients with bipolar mania, aripiprazole has been shown to be associated with weight gain after 4 weeks of treatment. Weight gain should be monitored in adolescent patients with bipolar mania.

What is the most common side effect of Abilify?

The most common adverse reactions in adult patients in clinical trials (≥10%) were nausea, vomiting, constipation, headache, dizziness, akathisia, anxiety, insomnia, and restlessness.

How does aripiprazole work as an anti psychotic?

Aripiprazole. Aripiprazole is a quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopamine and serotonin activity in the limbic and cortical system.

How is aripiprazole related to piperazines and quinolones?

Aripiprazole. Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. Aripiprazole is an Atypical Antipsychotic.

Which is a metabolite of the parent drug aripiprazole?

Pharmacokinetics Activity is presumably primarily due to the parent drug, aripiprazole, and to a lesser extent, to its major metabolite, dehydro-aripiprazole, which has been shown to have affinities for D2 receptors similar to the parent drug and represents 40% of the parent drug exposure in plasma.

What are the pharmacokinetics of aripiprazole at steady state?

Aripiprazole accumulation is predictable from single-dose pharmacokinetics. At steady- state, the pharmacokinetics of aripiprazole are dose-proportional. Elimination of aripiprazole is mainly through hepatic metabolism involving two P450 isozymes, CYP2D6 and CYP3A4.