How serious is osteonecrosis of the jaw?

It can cause tooth or jaw pain and swelling in your jaw. Severe symptoms include infection in your jaw bone. You can get ONJ after some dental surgeries, such as getting teeth extracted (removed) or implanted. If this happens, it may take a long time for you to heal after dental surgery or you may not heal at all.

Is necrosis of the jaw painful?

Osteonecrosis of the jaw is an oral lesion involving bare mandibular or maxillary bone. It may cause pain or may be asymptomatic. Diagnosis is by the presence of exposed bone for at least 8 weeks. Treatment is limited debridement, antibiotics, and oral rinses.

What causes jaw necrosis?

Osteonecrosis of the jaw can occur after tooth extraction, injury, radiation therapy, or for no apparent reason. Osteonecrosis of the jaw has occurred in some people taking high doses of bisphosphonate drugs intravenously, particularly if they have cancer or undergo oral surgery.

What causes the death of cells in karyorrhexis?

Necrotic cell death is comprised of a continuum of effects, culminating in nuclear pyknosis, karyorrhexis, and karyolysis. Numerous toxicants have been shown to cause both apoptosis and necrosis, with necrosis associated with higher doses and more severe toxicity.

What does karyorrhexis stand for in medical terms?

Karyorrhexis refers to apoptosis of infiltrating neutrophils producing pyknotic and fragmented nuclear debris (“nuclear dust”). M.C. Cohen, I. Scheimberg, in Encyclopedia of Forensic and Legal Medicine (Second Edition), 2016

What kind of bone disease does the jaw have?

Osteonecrosis of the jaw. Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature.

What causes cells in the jawbone to die?

Osteonecrosis of the jaw is a rare but serious condition in which the cells in the jawbone start to die. Osteonecrosis of the jaw can be caused by bisphosphonates, medicines used to strengthen bones: Actonel (chemical name: risedronate) Aredia (chemical name: pamidronate disodium) Bonefos (chemical name: clodronate)