Do fibroblasts become adipocytes?

Also, there is general agreement that fibroblasts can be transformed into adipocytes, a situation mimicking embryonic development when precursor fibroblast-like cells give origin to adipose tissues (3-5). However, the adult adipocytes in the fat depots are considered to be terminal cells (6,7).

What do cardiac fibroblasts do?

A major function of cardiac fibroblasts is to produce and secrete growth factors, cytokines and other signaling molecules. These signaling factors can have effects on all cardiac cell types. The specific signaling factors that are secreted by the cardiac fibroblasts largely depends on the stimuli.

Where are fibroblasts located in the heart?

Fibroblasts are found throughout the cardiac tissue, surrounding myocytes and bridging ‘the voids’ between myocardial tissue layers, so that, in essence, every cardiomyocyte is closely related to a fibroblast in normal cardiac tissue (Fig. 1).

How are cardiac fibro-adipocyte progenitors preferential differentiate to adipocytes?

Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene Circ Res. 2016 Jun 24;119(1):41-54.doi: 10.1161/CIRCRESAHA.115.308136.

How is the diversity of cardiac fibroblasts revealed?

This review aims to explore the diversity of cardiac fibroblasts and highlights new insights into the diverse nature of these cells and their progenitors as revealed by single cell sequencing and fate mapping studies.

Is the pericyte a fibroblast or stromal cell?

Pericytes are likely a distinct stromal cell type and not a fibroblast subtype. FAPs possess organ-specific transcriptional signatures and lineage biases. The cardiac stroma plays essential roles in health and following cardiac damage.

What is the cellular origin of fibroadipocytes in AC?

Cellular origin (s) of fibroadipocytes in AC is unknown. To identify the cellular origin of adipocytes in AC.