Can zosyn be given during dialysis?

Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g ZOSYN (0.67 g piperacillin/0.08 g tazobactam) should be administered following each dialysis period on hemodialysis days. No additional dosage of ZOSYN is necessary for CAPD patients.

Is hemodialysis the same as CRRT?

CRRT is a slower type of dialysis that puts less stress on the heart. Instead of doing it over four hours, CRRT is done 24 hours a day to slowly and continuously clean out waste products and fluid from the patient. It requires special anticoagulation to keep the dialysis circuit from clotting.

How often should you give a 4 hour infusion of Zosyn?

We can see that the 4 hour infusion given every 8 hours has a higher probability of achieving the target 50%fT>MIC when compared to the traditional dosing, even when it is given every 4 hours (that’s twice as much drug being administered).

When to use an extended infusion of PTZ?

Traditionally, PTZ has been given via a 30 minute intermittent-infusion. However, studies have shown that we can optimize the activity of PTZ to treat more resistant Gram-negative organisms, such as Pseudomonas aeruginosa, through the use of an extended-infusion (EI) given over 4 hours.

When to take extended infusion of piperacillin tazobactam?

Extended-Infusion Piperacillin/Tazobactam (Zosyn ®) Protocol for Adult Patients . 9/20/2016TTO . PURPOSE . Piperacillin-Tazobactam (PTZ) is a commonly used broad-spectrum β-lactam antibiotic. Like all β-lactam antibiotics, its bactericidal activity is dependent upon the percentage of time that free drug is above the minimum inhibitory

Which is high flux hemodialysis does intermittent HD assume?

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.