Which cancer is most responsive to chemotherapy?

Normal proliferating tissues like gastrointestinal mucosa or the bone marrow or hair follicles are the most susceptible to toxicity form chemotherapy.

What type of cells are targeted by chemotherapy?

The fact that chemotherapy drugs kill dividing cells helps to explain why chemotherapy causes side effects. It affects healthy body tissues where the cells are constantly growing and dividing, such as: your hair, which is always growing. your bone marrow, which is constantly producing blood cells.

Can cancer cells survive without mitochondria?

While many cancer cells can survive without the energy from mitochondria, they simply cannot grow without the ability to form new strands of DNA, which we now know mitochondria play a vital role in.”

Can mitochondria fight cancer?

Targeting a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy. A team of Hokkaido University scientists studied the molecules involved in mitochondrial movements within highly invasive breast cancer cells.

How does a damaged mitochondria lead to cancer?

Mitochondria and Cancer. The mitochondria malfunction and the cells revert to producing energy by fermentation rather than by processing oxygen. Other celluar processes go awry as a result. The damaged cell is desperately trying to survive its unhealty environment, which leads to cancer cells and eventually tumors.

How is the function of mitochondria related to apoptosis?

Mitochondrial function is so inextricably tied to apoptosis that tissue necrosis is one of the clinical features of mitochondrial diseases, such that extensive tissue damage can be incurred (8). Via their production of reactive oxygen species (ROS) as metabolic byproducts, mitochondria also regulate the cellular redox state.

What happens to a damaged mitrochondria in cancer?

The damaged cell is desperately trying to survive its unhealty environment, which leads to cancer cells and eventually tumors. Correcting the cellular environment can cause the cell and the mitrochondria to function normally again.

Why is the mitochondria a semi autonomous organelle?

Because most of the mitochondrial genome is scattered throughout chromosomal DNA, the mitochondria is referred to as a semi-autonomous organelle, as it relies on communication with the nucleus for expression of all its enzyme complexes and molecular constituents (5).