What is zieve syndrome?

Zieve’s syndrome (ZS) is a triad of jaundice, hemolytic anemia, and hyperlipidemia that develops secondary to alcohol-induced liver injury [1]. It was first described by Dr. Leslie Zieve in 1957. Patients with ZS present with abdominal pain, nausea, and other nonspecific symptoms [1].

How is alcoholic steatohepatitis diagnosed?

Once the symptoms have been discussed and it is determined that it may be steatohepatitis, a biopsy of the liver will be done, as this is the only way to make a definitive diagnosis and exclude any other causes. An ultrasound can determine the extent of the damage as well as CT scans and MRIs.

Does alcoholism cause hemolytic anemia?

Hemolytic Anemia In Alcoholics This is where the relationship between anemia and alcoholism gets particularly dangerous. Hemolytic anemia may result in a spur-shaped RBC or the neutrophil may be abnormally structured. When these cells die, the bone marrow can’t produce enough to meet the body’s demands.

Does cirrhosis cause hemolytic anemia?

Liver disease, particularly alcoholic cirrhosis, is associated with a number of interesting chemical changes which result in structural and metabolic abnormalities of the erythrocyte membrane leading to microscopically observable cell shape changes and hemolytic anemia varying from very mild to potentially lethal.

How is Zieve syndrome related to alcoholic liver disease?

The diagnosis of Zieve syndrome was confirmed based on hemolysis and cholestatic jaundice secondary to alcoholic liver disease and heavy drinking. Bone marrow biopsy and liver biopsy both supported the diagnosis. We treated her with abstinence from alcohol and supportive therapy.

What are the symptoms of Zieve’s syndrome?

Zieve’s syndrome (ZS) is a clinical syndrome that presents with a triad of jaundice, hemolytic anemia, and hyperlipidemia secondary to alcohol use. Herein, we present a case of a 58-year-old male with a history of liver cirrhosis who presented after a fall due to binge drinking and was found to have severe anemia.

Who was the first person to have Zieve’s syndrome?

Zieve’s syndrome was initially described in 1958. Dr. Leslie Zieve described patients with a combination of alcoholic liver disease, hemolytic anemia and hypertriglyceridemia.

How are glucocorticoids used to treat Zieve syndrome?

Recognition of this syndrome could help doctors avoid unnecessary invasive procedures and emphasize the importance of alcohol abstinence as the mainstay of management. Glucocorticoids may not be useful in treating hemolytic anemia in Zieve syndrome.