What is the sensitivity and specificity of PSA?

A systematic review estimated that the PSA cutoff of 4.0 ng/mL had a sensitivity of 21 percent with specificity of 91 percent for detection of any prostate cancer; for detection of a high-grade cancer, sensitivity was 51 percent [28].

What is the sensitivity of the new assay for PSA?

Prostate-specific antigen (PSA) testing with a cutoff of 4.0 ng/mL has a sensitivity of 67.5-80%, which implies that 20-30% of cancers are missed when only the PSA level is obtained.

Does DRE increase PSA?

Some studies have suggested that a digital rectal exam (DRE) might raise PSA levels slightly, although other studies have not found this. Still, if both a PSA test and a DRE are being done during a doctor visit, some doctors advise having the blood drawn for the PSA before having the DRE, just in case.

Is there a screening Programme for prostate cancer?

There’s currently no screening programme for prostate cancer in the UK. This is because it has not been proved that the benefits would outweigh the risks.

What is normal range for PSA?

Decoding a PSA Test The median PSA for this age range is 0.6 to 0.7 ng/ml. For men in their 60s: A PSA score greater than 4.0 ng/ml is considered abnormal. The normal range is between 1.0 and 1.5 ng/ml. An abnormal rise: A PSA score may also be considered abnormal if it rises a certain amount in a single year.

What is the normal PSA for a 70 year old man?

For men aged 70 to 79, they suggested a normal serum PSA reference range of 0.0–6.5 ng/mL (0.0–6.5 μg/L).

What can cause PSA to rise quickly?

High PSA? Here are 7 common things that can affect your PSA level

• Age. Older men’s normal PSA levels run a little higher than those of younger men.
• Prostate size.
• Prostatitis.
• Benign prostatic hyperplasia (BPH)
• Urinary tract infection or irritation.
• Prostate stimulation.
• Medications.

What’s the sensitivity and specificity of prostate cancer?

For prostate cancer, the standard PSA cut-off of 4 ng/mL has low sensitivity: with this cut-off only 20.5% of the prostate cancer cases test positive-nearly 80% of prostate cancer cases are missed. The specificity at this cut-off is high (93.6%) meaning only 6.2% of men who do not have prostate cancer falsely test positive.

What are the specificity and sensitivity of 68Ga-PSMA?

Shorter PSA doubling time increased 68Ga-PSMA PET positivity. On per-patient analysis, the summary sensitivity and specificity were both 86%. On per-lesion analysis, the summary sensitivity and specificity were 80% and 97%, respectively.

What is the sensitivity and specificity of a PPV test?

For any given test, as disease prevalence in the population being tested increases, the PPV of that test will also increase. Positive Predictive Values (PPV) Test with 90% Sensitivity and 90% Specificity in a Population with Disease Prevalence of 1%  PPV = .08 (8%)

When does the specificity of a screening test decrease?

A specific test is usually negative in disease free patients (few false positives ). When many disease free patients have a positive test (false positives), the specificity decreases. Utility as a screening test may diminish because it results in too many needless work-ups. 14 Cutoff Points 1.