What is the origin of osteosarcoma?

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring during the rapid growth phase of long bones, and usually located in the epiphyseal growth plates of the femur or the tibia.

What cells does osteosarcoma come from?

Osteosarcoma is a type of bone cancer that usually develops in the osteoblast cells that form bone. It happens most often in children, adolescents, and young adults. Approximately 800 new cases of osteosarcoma are reported each year in the U.S.

Where does osteosarcoma spread first?

Most often it spreads to the lungs, but it can also spread to other bones, the brain, or other organs. About 1 out of 5 osteosarcomas have spread already when they are first diagnosed.

What is the most common site for metastasis from an osteosarcoma?

Osteosarcoma is the most common primary bone tumor in children and young adults arising from primitive mesenchymal bone-forming cells. The lung is the most common site of metastasis of osteosarcoma.

Which is rare Interdigitating dendritic cell sarcoma?

Interdigitating dendritic cell tumor (sarcoma) is an extremely rare neoplasm consisting of cells with spindle-shaped nuclei and immunophenotypic features similar to the IDC [5, 146]. Lymphadenopathy is the most frequent clinical findings which may present as localized or generalized.

How is follicular dendritic cell sarcoma similar to lymphoma?

Follicular dendritic cell sarcoma (FDC sarcoma) is a very rare type of blood cancer. It is similar to lymphoma, but doctors usually treat it as a soft tissue sarcoma. FDC sarcoma develops from specialised cells in the lymph nodes. The lymph nodes are part of the lymphatic system, which helps to fight infection.

What was the treatment for follicular dendritic cell sarcoma?

At the time of the follicular dendritic cell sarcoma discovery, information on the effect of chemotherapy and radiation on it was nonexistent. The best physicians could do was try existing chemotherapeutic agents.

What was the origin and development of dendritic cells?

Origin and development of dendritic cells Immunol Rev. 2010 Mar;234(1):45-54.doi: 10.1111/j.0105-2896