What is the function of fibronectin?

Specific domains allow fibronectin to promote cell-to-cell adhesion, cell-to-basement-membrane attachment, clot stabilization, embryogenesis, nerve regeneration, fibroblast migration, macrophage function, and pathogen (virus, fungus, bacteria, and protozoa) binding to mammalian cells and extracellular matrix.

What fibronectin means?

: any of a group of glycoproteins of cell surfaces, blood plasma, and connective tissue that promote cellular adhesion and migration.

What is the difference between fibronectin and fibrinogen?

Following vascular injury, fibrinogen is activated by thrombin to form an insoluble fibrin clot that prevents the loss of blood. First, fibronectin binds reversibly to fibrin and then becomes covalently cross-linked to it by factor XIIIa.

What are fibronectin and laminin?

Fibronectin stimulates the adhesion of fibroblasts, but not epidermal cells, to collagen type IV (ref. 7) and could mediate the attachment of sarcoma cells. While laminin mediates the attachment and spreading of the former fibronectin is responsible for the attachment and flattening of the latter.

What are the functions of the fibronectin matrix?

The fibronectin matrix is important for embryogenesis, cell adhesion, and growth [2 ]. As a circulating protein, fibronectin is involved in wound healing, hemostasis, and platelet aggregation.

What is the function of fibronectin in wound healing?

As a circulating protein, fibronectin is involved in wound healing, hemostasis, and platelet aggregation. Functional domains of fibronectin mediate interactions with cell surface receptors and a number of other macromolecules including fibrin, fibrinogen, collagen, heparin, immune complexes, and fibronectin itself.

Where does fibronectin assemble on the cell surface?

Fibronectin (FN) is a plasma glycoprotein produced by hepatocytes that circulates at near micromolar concentration and assembles into extracellular matrix fibrils at cell surfaces along with locally produced cellular FN.

What can fibronectin do for neural stem cells?

Fibronectin surfaces can also serve as substrates for culturing neural stem cells derived from mammalian pluripotent stem cells. It also increases neural stem cell survival when added to cell culture media, suggesting its potential as cell culture supplement [86].