What is the drug of choice for P vivax malaria?

Chloroquine (or hydroxychloroquine), remains an effective choice for P. vivax and P. ovale infections except for P. vivax infections acquired in Papua New Guinea or Indonesia, countries with high prevalence of chloroquine-resistant P.

How do you treat P vivax malaria?

Currently, P. vivax malaria is treated with chloroquine or artemisinin combination therapy (ACT) for the blood stage infection. While chloroquine has been standard treatment for vivax malaria for some 70 years, the emergence and global spread of chloroquine resistance in P.

Is P vivax fatal?

Vivax malaria is a potentially life threatening infection despite relatively low-grade parasitaemia in peripheral blood [2]. P. vivax infections have lower parasite biomass compared with P. falciparum malaria patients of the given age.

What is the cost of malaria?

The average cost of treating a patient with chloroquine worked out to Rs. 1068/- the cost of treating a patient with mefloquine worked out to Rs. 1188/- and the cost of treating a patient with co artemether worked out to Rs. 1051/- (excluding drug cost, since the drug is not marketed in India, Table 2).

Which are the best anti malaria tablets?

There are currently three recommended treatments for severe and complicated malaria: artesunate (AS), artemether (AM) and quinine (or quinidine), although in many countries only quinine is available.

Does milk affect malaria drugs?

Milk has been used as a vehicle for the delivery of antimalarial drugs during clinical trials to test for a food effect and artefenomel (OZ439) showed enhanced oral bioavailability with milk.

Can P vivax cause severe malaria?

Contrary to the widespread belief that severe malaria is mainly caused by Plasmodium falciparum, malaria caused by Plasmodium vivax infection may also lead to severe clinical manifestations including a plethora of renal, pulmonary, hematologic, neurologic, and multiorgan dysfunction.

What is Black Water disease?

Abstract. Blackwater fever (BWF) is a severe clinical syndrome, characterized by intravascular hemolysis, hemoglobinuria, and acute renal failure that is classically seen in European expatriates chronically exposed to Plasmodium falciparum and irregularly taking quinine.

Is it expensive to treat malaria?

The median financial cost of treating an episode of uncomplicated malaria was $5.84 (range $2.36-$23.65) and the median financial cost of treating an episode of severe malaria was $30.26 (range $15.64-$137.87).