What is the difference between EPS and NMS?

Rapid, increasing signs of extrapyramidal symptoms (EPS) is an important key feature of NMS. EPS, associated with conventional antipsychotics, occurs in about 95% of NMS cases. The potential for atypicals to produce EPS symptoms in NMS is comparable to that of conventional antipsychotics.

What are symptoms of neuroleptic malignant syndrome?

Symptoms of neuroleptic malignant syndrome usually include very high fever (102 to 104 degrees F), irregular pulse, accelerated heartbeat (tachycardia), increased rate of respiration (tachypnea), muscle rigidity, altered mental status, autonomic nervous system dysfunction resulting in high or low blood pressure.

How is NMS diagnosed?

Diagnosis. Your doctor will look for the two main symptoms of NMS: a high temperature and stiff muscles. To be diagnosed with it, you also need to have a few other warning signs, like a fast heartbeat, low or high blood pressure, and sweating. Some other disorders have symptoms that are similar to NMS.

How does neuroleptic malignant syndrome happen?

Neuroleptic malignant syndrome (NMS) is a severe disorder caused by an adverse reaction to medications with dopamine receptor-antagonist properties or the rapid withdrawal of dopaminergic medications.

What’s the difference between NMS and serotonin syndrome?

Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management SS presents as mental status changes, autonomic nervous system disturbances, neurologic manifestations, and hyperthermia. Similarly, NMS presents as muscle rigidity, hyperpyrexia, mental status changes, and autonomic instability.

Is there a connection between NMS and SS?

Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are two rare, but serious adverse reactions associated with psychotropic medications. While the disorders may share certain features, there are differences in how they are managed and treated. This article reviews the risk factors, clinical presentation, and treatment of SS and NMS.

What makes NMs different from neuroleptic malignant syndrome?

However, the clinical laboratory profile of elevations in creatine kinase, liver function tests (lactate dehydrogenase, aspartate transaminase), and white blood cell count, coupled with a low serum iron level, distinguishes NMS from SS among patients taking neuroleptic and serotonin agonist medications simultaneously.

Which is rare serotonin syndrome or neuroleptic malignant syndrome?

Neuroleptic malignant syndrome (NMS) and serotonin syndrome are rare, life-threatening, medicine-induced disorders 1. Both syndromes share clinical features, such as pyrexia, hypertonia and changes in mental state, making differentiation difficult 1. Differentiation is important as pharmacologic treatment is dependent on the causative agent.