What is Inamrinone used for?

Inamrinone is a medication used in the short-term management and treatment of congestive heart failure. It is a phosphodiesterase-III inhibitor, which increases cardiac inotropy.

What is the status for Inamrinone?

Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure….Amrinone.

What are the most common adverse reactions for Inamrinone?

Gastrointestinal Effects: Gastrointestinal adverse reactions reported with Inamrinone during clinical use included nausea (1.7%), vomiting (0.9%), abdominal pain (0.4%), and anorexia (0.4%). Cardiovascular Effects: Cardiovascular adverse reactions reported with Inamrinone include arrhythmia (3%) and hypotension (1.3%).

What is a milrinone pump?

This medication is used for the short-term treatment of heart failure. It works by making your heart beat stronger and by relaxing certain blood vessels so that the amount of blood that is pumped from the heart is increased. This effect may help with symptoms of heart failure (such as shortness of breath, tiredness).

How long does an intravenous inamrinone injection last?

Following intravenous bolus (1 to 2 minutes) injection of 0.68 mg/kg to 1.2 mg/kg to normal volunteers, Inamrinone had a volume of distribution of 1.2 liters/kg, and following a distributive phase half-life of about 4.6 minutes in plasma, had a mean apparent first-order terminal elimination half-life of about 3.6 hours.

How is inamrinone used to treat heart disease?

Inamrinone belongs to a group of drugs called cardiac inotropic agents, which help the heart increase its ability to beat. It also relaxes the blood vessels so the heart does not have to pump as hard. This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

How many milligrams of inamrinone are in a vial?

The solubilities of Inamrinone at pH’s 4.1, 6.0, and 8.0 are 25, 0.9, and 0.7 mg/mL, respectively. Inamrinone injection is a clear yellow sterile solution available in 20 mL vials for intravenous administration.

Are there any side effects to taking inamrinone?

While Inamrinone per se has not been shown to be arrhythmogenic, the potential for arrhythmia, present in congestive heart failure itself, may be increased by any drug or combination of drugs. Thrombocytopenia and hepatotoxicity have been noted (see ADVERSE REACTIONS ).