What is fetal hydantoin syndrome?

Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure (anticonvulsant) drug phenytoin (Dilantin) during pregnancy. The range and severity of associated abnormalities will vary greatly from one infant to another.

Which of the following drug may produce fetal hydantoin syndrome?

Fetal hydantoin syndrome is a disorder that is caused by exposure of a fetus to phenytoin, a drug commonly prescribed for epilepsy . Not all infants exposed to phenytoin will be affected with the disorder.

What is the teratogenic effect of phenytoin?

Background: The antiepileptic drug phenytoin (PHT) is a human and animal teratogen. The teratogenicity has been linked to PHT-induced embryonic cardiac arrhythmia and hypoxic damage during a period when regulation of embryonic heart rhythm is highly dependent on a specific K(+) ion current (I(Kr)).

Is phenytoin safe in pregnancy?

This drug should not be used during pregnancy unless the benefit outweighs the risk to the fetus. Comments: -If this drug is used during pregnancy, or if the patient becomes pregnant while taking the drug, the patient should be informed of the potential harm to the fetus.

What birth defects can retinol cause?

Use of 13-cis-retinoic acid by women during pregnancy also can results in developmental irregularities in fetuses and children, such as cleft palates, absent or abnormally small ears, heart defects, and thymus abnormalities.

What does phenytoin do to fetus?

But the medicine can cause birth defects if a woman takes it during pregnancy. A baby born to a mother who took phenytoin has a 5 in 100 to a 1 in 10 chance of having a birth defect. This birth defect is a combination of problems called fetal hydantoin syndrome.

How does phenytoin affect a fetus?

Today, the known potential adverse effects of phenytoin on the fetus include facial clefting, vitamin K and D deficiencies, heart malformations, limb deformities, and neurologic defects.

What is the safest anticonvulsant in pregnancy?

Of the new anti-seizure medications, lamotrigine and levetiracetam are the most widely used due to their known safety during pregnancy. Clearance of lamotrigine and levetiracetam doubles during pregnancy compared to before pregnancy.

Can a guy get a girl pregnant while on Accutane?

There has been no known adverse effect on the pregnancy if a man taking isotretinoin fathers a child. However, as isotretinoin is present in semen, it may be a sensible precaution to use a condom to avoid transmission of any of the drug to females.

Is it OK to use vitamin C serum while pregnant?

This is why Jasmina Vico, a skin expert, recommends using a vitamin C serum every single day during your pregnancy to help brighten dark spots and pigmentation, as well as accentuating that maternal glowy complexion.

Can phenytoin cause birth defects?

Phenytoin is a medicine used to treat seizures (epilepsy). But the medicine can cause birth defects if a woman takes it during pregnancy. A baby born to a mother who took phenytoin has a 5 in 100 to a 1 in 10 chance of having a birth defect.

Can phenytoin cause cleft palate?

Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. Teratology.

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