What is a translocation heterozygote?

An individual or cell in which two pairs of homologous chromosomes have reciprocally exchanged nonhomologous segments between one member of each pair.

What does reciprocal translocation cause?

Reciprocal translocations Such translocations are usually harmless and may be found through prenatal diagnosis. However, carriers of balanced reciprocal translocations have increased risks of creating gametes with unbalanced chromosome translocations, leading to Infertility, miscarriages or children with abnormalities.

What is homologous translocation?

Translocation is a genetic mutation which refers to an exchange of chromosome segments. [1] The centric translocation of homologous chromosomes can occur between 13;13, 14;14, 15;15, 21;21 and 22;22. The commonly seen homologous chromosomal translocations in live-births are for chromosome 13 and 21.

Which is the best definition of reciprocal translocation?

reciprocal translocation the mutual exchange of fragments between two broken chromosomes, one part of one uniting with part of the other. robertsonian translocation that in which the breaks occur at the centromeres and entire chromosome arms are exchanged, usually involving two acrocentric chromosomes.

Which is the best definition of a translocation heterozygote?

translocation heterozygote. an individual carrying cells with one normal set of chromosomes and one set in which a reciprocal TRANSLOCATION has occurred between two non-HOMOLOGOUS CHROMOSOMES. See Fig. 304 . Such an event causes pairing problems in prophase 1 of MEIOSIS when the chromatids undergo SYNAPSIS (2).

Are there reciprocal translocations between chromosomes 2 and 3?

Reciprocal translocations are found in approximately 3% of couples with recurrent miscarriage. Figure 2.3 •. Reciprocal translocation between chromosomes 2 and 3. A portion of the short arm of chromosome 2 has been exchanged with a small portion of the long arm of chromosome 3. The panel on the left shows this in diagrammatic form.

Can a fetus be affected by a reciprocal translocation?

The long or short arms of any chromosomes may be involved. When a fetus has inherited a parental apparently balanced reciprocal translocation, there appears to be no increased incidence of phenotypic abnormality in the child, especially if the translocation is present without effect in several family members.