What is a contraindication of administering tPA in frostbite patients?

Contraindications to the use of tPA in the Twomey study included: Severe hypertension, recent trauma, stroke, or bleeding disorder, pregnancy, mental incapacity, drug or alcohol intoxication, repeated freeze-thaw cycles, or more than 48 hours of cold exposure.

What are contraindications to alteplase?

Absolute contraindications for alteplase therapy for AIS include the following:

• History or evidence of ICH.
• Clinical presentation suggestive of SAH.
• Known arteriovenous malformation.
• Systolic BP exceeding 185 mm Hg or diastolic BP exceeding 110 mm Hg despite repeated measurements and treatment.

Does frostbite lead to amputation?

The nose, cheeks, ears, fingers, and toes are the extremities most commonly affected. The condition results in a loss of feeling and color in the affected area and can cause permanent tissue damage. In severe cases, frostbite can lead to amputation of the extremity.

Do steroids help frostbite?

The affected skin should be rewarmed, gently bandaged, and elevated. Some European studies support the use of nifedipine , at a dose of 20 mg t.i.d, as both prophylactic and therapeutic. Topical corticosteroids , or even a brief burst of oral corticosteroids, such as prednisone, have been shown to be useful.

Who should not be given tPA?

Elevated blood pressure (systolic greater than 185 mmHg or diastolic greater than 110 mmHg) Active internal bleeding. Acute bleeding diathesis, including but not limited to. Platelet count less than 100 000/mm^3.

Is aspirin a contraindication for tPA?

However, it should be noted that pre-TPA aspirin use was not associated with an increased ICH risk in patients given the drug (16) and therefore pre-morbid aspirin use is not considered a contraindication for TPA administration in acute stroke.

Are there preservatives in technetium Tc 99m pentetate injection?

Kit for the Preparation of Technetium TC 99M Pentetate Injection contains no preservative. Vials are sealed under nitrogen: air or oxygen is harmful to the contents of the vials and the vials should not be vented. The components of Kit for the Preparation of Technetium TC 99M Pentetate Injection are supplied sterile and non-pyrogenic.

When to use technetium Tc 99m in children?

Technetium Tc 99m is excreted in human milk during lactation, therefore, formula feedings should be substituted for breast feeding. Pediatric Use Safety and effectiveness in pediatric patients under the age of 30 days have not been established.

Is it safe to give technetium to a pregnant woman?

It is also not known whether Technetium TC 99M Pentetate Injection can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. There have been no studies in pregnant women. Technetium TC 99M Pentetate Injection should be given to a pregnant woman only if clearly needed.

How long does it take to clear technetium Tc 99m mertiatide?

In healthy subjects with normal renal function (mean serum creatinine 1.2 mg/dL) Technetium TC 99M Mertiatide was rapidly cleared from the blood. The plasma clearance was approximately 0.3 liters/minute and the amount of Technetium TC 99M Mertiatide excreted in the urine in three hours was nearly 90% of the dose.

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