What does an abnormal liver function test mean?

Your liver tests can be abnormal because: Your liver is inflamed (for example, by infection, toxic substances like alcohol and some medicines, or by an immune condition). Your liver cells have been damaged (for example, by toxic substances, such as alcohol, paracetamol, poisons).

What can cause abnormal LFTs?

More common causes of elevated liver enzymes include:

• Over-the-counter pain medications, particularly acetaminophen (Tylenol, others)
• Certain prescription medications, including statin drugs used to control cholesterol.
• Drinking alcohol.
• Heart failure.
• Hepatitis A.
• Hepatitis B.
• Hepatitis C.
• Nonalcoholic fatty liver disease.

What is another name for LFT?

Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient’s liver. These tests include prothrombin time (PT/INR), activated Partial Thromboplastin Time (aPTT), albumin, bilirubin (direct and indirect), and others.

What does LFT derangement mean?

Deranged LFT was defined as any biochemical parameter of LFT that is 1.5 times above the reference range. Results: There were 39 males and the median age was 51 (range 20-73) years old. Median duration of HPN was 40 (range 6-252) months.

What are the red flags for abnormal LFTs test?

Go to A-1. Guidelines Summary: Incidental Finding of Abnormal Liver Function Tests Red Flags: 1. Jaundice 2. Hepatomegaly/irregular liver 3. Splenomegaly 4. Low platelets 5. Low albumin/Prolonged PT *For components of chronic liver disease screen and metabolic syndrome, please refer to text Chronic Liver Disease Screen • Viral – HepBsAg – HCV Ab

How to determine the likely cause of LFT derangement?

The AST/ALT ratio can be used to determine the likely cause of LFT derangement: Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates.

Which is the correct reference range for LFT?

The actual LFT’s with adult reference ranges are as follows; • Bilirubin (< 21 µmol/L) • ALT (< 40 IU/L) • ALP (♀ below 60y 35 – 104 IU/L; ♂ & ♀ above 60y 40 – 129 IU/L) • Total Protein (60 – 80 g/L) • Albumin (35 – 50 g/L)

When to repeat the LFT for liver function?

In asymptomatic patients who have minor liver enzyme elevations (i.e. less than twice the upper limit of normal), the LFT should be repeated on a follow-up sample to conrm the result. Hepatocellular pattern: There is a disproportionate elevation in the aminotransferases (AST and ALT) compared with Alk phos;bilirubin may be elevated.

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