What class of antibiotics are macrolides?

Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.

What classification is macrolides?

Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Macrolides are bacteriostatic in that they suppress or inhibit bacterial growth rather than killing bacteria completely.

What are the members of the macrolide class of antibiotics?

The macrolide antibiotics are an important class of orally active antibiotics. 18 Major members of the class include erythromycin and azithromycin, as well as telithromycin, which was approved in 2004 (Figure 4).

How are macrolides used to treat bacterial infections?

What are Macrolides? Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.

What’s the difference between macrolide and ketolide antibiotics?

Comparison of macrolide antibiotics erythromycin, clarithromycin, azithromycin, telithromycin, roxithromycin: mechanism of action, spectrum of activity, side effects, drug interactions. Macrolide & Ketolide Antibiotics Comparison Classification of macrolides[Table 1] Mechanism of action[Video] Spectrum of activity Indications and uses[Infographic]

How are serum levels of macrolide antibiotics determined?

Only chromatographic methods are available for determination of serum or plasma levels of these antibiotics. Macrolide antibiotics, such as erythromycin, azithromycin, and clarithromycin, can be readily analyzed using chromatographic techniques with solid phase or liquid–liquid extraction.