What are synthons and synthetic equivalent?

December 15, 2019 Posted by Madhu. The key difference between synthon and synthetic equivalent is that synthon is a moiety of a chemical compound that can be formed by a known synthetic process, whereas synthetic equivalent is a reagent that carries out the function of a synthon.

What is illogical synthon?

Disconnection of a bond of a target molecule gives positively charged (electrophilic) synthons where the normal polarity is reversed then the synthon is called an unnatural or illogical electrophilic synthon, and the corresponding synthetic equivalent is called illogical electrophilic synthetic equivalent or illogical …

What do you mean by retrosynthetic analysis?

Retrosynthetic analysis (retrosynthesis) is a technique for planning a synthesis, especially of complex organic molecules, whereby the complex target molecule (TM) is reduced into a sequence of progressively simpler structures along a pathway which ultimately leads to the identification of a simple or commercially …

What is the meaning of synthons?

A synthon is a concept in retrosynthetic analysis. It is defined as a destructural unit within a molecule which is related to a possible synthetic operation. The term was coined in 1968 by E.J. Corey.

What is mean by synthetic equivalent?

Synthetic equivalents are the chemical species which is used to generate synthons. They are the actual substrates used for the forward reaction and hence forward synthesis. Also, the synthetic equivalents are the reagents derived from inverting the polarity of synthons.

What are synthons give examples?

Example. In planning the synthesis of phenylacetic acid, two synthons are identified: a nucleophilic “COOH−” group, and an electrophilic “PhCH2+” group. In this case, the cyanide anion is the synthetic equivalent for the COOH− synthon, while benzyl bromide is the synthetic equivalent for the benzyl synthon.

What are Synthons with examples?

Example

• C2 synthons – acetylene, acetaldehyde.
• -C2H4OH synthon – ethylene oxide.
• carbocation synthons – alkyl halides.
• carbanion synthons – Grignard reagents, organolithiums, substituted acetylides.

What is acceptor synthon?

Heterolytic cleavage for disconnection of a carbon-carbon bond in a molecule breaks the target molecule an acceptor synthon (a carbocation) and a donor synthon, (a carbanion).

What is reactivity Umpolung explain with example?

The original meaning of the term has been extended to the reversal of any commonly accepted reactivity pattern. For example, reaction of R-C CX (X = halide) as a synthon for “R-C C+ (i.e. electrophilic acetylene) is an umpolung of the normal more common acetylide, R-C. C- (i.e. nucleophilic) reactivity.

What FGI means?

Finished Goods Inventory. FGI. Fashion Group International, Inc. FGI.

Who invented Retrosynthesis?

Beginning in the 1960’s, Corey coined the term, and developed the concept of, retrosynthetic analysis. Starting from the structure of the molecule he was to produce, the target molecule, he established rules for how it should be dissected into smaller parts, and what strategic bonds should be broken.

Which is an example of a synthetic equivalent?

Synthetic equivalent is a reagent that carries out the function of a synthon. Synthons are reacted with the corresponding synthetic equivalent to obtain the desired target molecule. For example, the synthetic equivalent for carboxylic acid group in the synthesis of phenylacetic acid is cyanide anion.

Which is the synthetic equivalent of the COOH synthon?

Of course, both synthons do not exist per se; synthetic equivalents corresponding to the synthons are reacted to produce the desired reactant. In this case, the cyanide anion is the synthetic equivalent for the COOH − synthon, while benzyl bromide is the synthetic equivalent for the benzyl synthon.

How is a synthon different from a synthetic moiety?

Synthon is a moiety of a chemical compound which can be formed by a known synthetic process. It is a hypothetical unit within a target chemical compound (organic compound). A synthon represents the potential starting reagent for the retroactive synthesis of that target molecule.

Who was the first person to use the term synthon?

The term was coined in 1967 by E. J. Corey. He noted in 1988 that the “word synthon has now come to be used to mean synthetic building block rather than retrosynthetic fragmentation structures”.