Is prothrombin gene mutation recessive?

Many people with prothrombin-related thrombophilia never develop abnormal blood clots. This condition is caused by a particular genetic variant (written G20210A or 20210G>A) in the F2 gene and is inherited in an autosomal dominant pattern.

What is a prothrombin gene mutation?

The Prothrombin Gene Mutation is a change in the gene that controls a blood clotting protein that circulates in the blood called prothrombin. This particular gene change leads to an increase in the level of this protein in the blood.

Is prothrombin gene mutation curable?

No treatment can prevent the prothrombin gene mutation or make it go away. The goal of treatment is to prevent blood clots (see next question and page 7). If you have had a blood clot, you may be treated with medications called anticoagulants.

How common is prothrombin mutation?

A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation. Prothrombin G20210A mutation is rare in other groups.

What happens to prothrombin in the second trimester?

Prothrombin Time (Plasma) During Pregnancy. Pregnancy Trimester Two: 9.5 to 13.4 seconds Pregnancy Trimester Three: 9.6 to 12.9 seconds Impaired prothrombin time can cause excessive bleeding or bruising. If the patient is suffering from vitamin K deficiency, prothrombin and other clotting elements in blood cannot be produced in adequate amounts.

How is prothrombin gene mutation treated in pregnancy?

How Is Prothrombin Gene Mutation in Pregnancy Treated? If a woman has a prothrombin mutation, she may want to consider having anticoagulation therapy during and right after her pregnancy. In this type of therapy, medications are used during the course of a pregnancy to help thin out the blood and prevent blood clots from forming.

Can a woman with a prothrombin mutation get a blood clot?

Most people with prothrombin mutations will never develop an abnormal blood clot. But women who are pregnant already have a higher risk of getting a clot during and right after pregnancy. If a pregnant woman also has a prothrombin mutation, she will have a higher risk of blood clots.

What do you need to know about prothrombin time test?

Prothrombin time test. Overview. A prothrombin time test measures how quickly your blood clots. Sometimes called a PT or pro time test, a prothrombin time test uses a sample of your blood. Prothrombin is a protein produced by your liver. It is one of many factors in your blood that help it to clot appropriately.