Why do aspirin and NSAIDs cause stomach upset and ulcers?

By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect on prostaglandins in the stomach than others, and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists.

Can you be allergic to aspirin but not ibuprofen?

D. Reactions to aspirin are common. If you have an aspirin allergy or sensitivity, you may also have a reaction to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).

What is the most common side effect of aspirin and NSAIDs?

The most common side effects of aspirin and NSAIDs are gastrointestinal (GI), and include: Nausea. Vomiting. Diarrhea.

How do NSAIDs interfere with aspirin?

How does ibuprofen work and why does it interact with aspirin? All NSAIDs work by inhibiting the enzyme cyclooxygenase (COX). Aspirin inhibits COX irreversibly, while all non-aspirin NSAIDs are reversible inhibitors of COX.

Can a sensitive patient take an aspirin or NSAID?

Make sure to administer the NSAID to sensitive patients in a location where a reaction may be controlled. Patients with underlying AERD or chronic urticaria should not receive aspirin or COX-1 inhibitor but may try COX-2 inhibitors for acute use if underlying diseases are controlled.

Can a non steroidal anti inflammatory cause a peptic ulcer?

A second, less common, but steadily increasing in importance, cause of peptic ulcers is the use of non-steroidal anti-inflammatory medications (NSAIDs). Using over-the-counter NSAIDs, such as aspirin or ibuprofen for the occasional headache or achy back won’t cause a peptic ulcer.

Who is at risk for aspirin hypersensitivity?

This article provides information on the pathogenesis of aspirin hypersensitivity, cross-sensitivity, and cross-tolerance of different NSAIDs in patients with respiratory types of reactions. Hypersensitivity to aspirin may affect 5-20% of patients with chronic asthma and an unknown fraction of patients with chronic urticaria-angioedema.

Why does aspirin cause a peptic ulcer in the stomach?

NSAIDs such as aspirin, ibuprofen, and naproxen, can cause ulcers by interfering with the stomach’s ability to protect itself from gastric acids. While stomach acids are vital to the digestive process, they can cause damage if the protective barriers of the stomach are compromised.