Which antibody is responsible for SLE?

Definition. Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that results from widespread immune complex deposition and secondary tissue injury. It is characterized by the presence of antinuclear antibodies (ANAs) and multiple organ system involvement.

Which of the following antibodies are most specific to SLE?

The most specific antibody for SLE is the anti-Smith antibody; however, the sensitivity is only 30%-40%. Antinuclear antibody (ANA) is used for screening and has a sensitivity of 95%. Anti-Ro antibodies are present in 15% of patients with SLE and other connective tissue diseases.

What antibodies are involved in lupus?

The anti-double-stranded DNA antibody (anti-dsDNA) is a specific type of ANA antibody found in about 30% of people with systemic lupus. Less than 1% of healthy individuals have this antibody, making it helpful in confirming a diagnosis of systemic lupus.

What are the antigens in SLE?

Among the different autoantigenic candidates that are recognized by autoantibodies in SLE, there are only two nuclear antigens that are considered pathognomonic of SLE, double-stranded DNA (dsDNA) and the Sm antigens of the U-1 small nuclear ribonucleoprotein complex [2].

How can I boost my immune system with lupus?

Diet: For lupus patients, a healthy, well-balanced diet is particularly important for strengthening the ability to fight off disease. Foods high in saturated fat, trans fat, cholesterol, sodium and sugar should be avoided. Fruits and vegetables, fiber-rich whole grains, fish, nuts, legumes and seeds are recommended.

Is SLE an autoimmune disease?

Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels.

What diseases does ANA test for?

ANA may be detected in several disorders, including:

• Systemic lupus erythematosus.
• Sjögren’s syndrome.
• Polymyositis and dermatomyositis.
• Juvenile idiopathic arthritis.
• Raynaud’s phenomenon.
• Drug-induced lupus.
• Mixed connective tissue disease.
• Autoimmune hepatitis.

Are eggs bad for lupus?

Eating foods like fish, nuts, seeds, tofu, tempeh, and eggs may be helpful. You may also have some new food challenges because of the medication your doctor has prescribed. A corticosteroid, for instance, can cause weight gain and high blood sugar.

Which is the antibody most specific for SLE?

The antinuclear antibody (ANA) test is the most commonly used screening test for SLE. The presence of anti-DNA, anti-Sm, and antiphospholipid antibodies is more specific for diagnosing SLE.

What causes lupus anticoagulant?

Lupus anticoagulant syndrome is caused by production of antibodies against plasma proteins in the blood, which results in their destruction. This can cause high risk of clotting. Exact cause for this condition is unknown.

What is systemic lupus erythematosus (SLE)?

Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs.

What is positive lupus anticoagulant?

What a Positive Lupus Anticoagulant Antibodies Test Means. Lupus anticoagulant antibodies are one of the markers for antiphospholipid syndrome, a disorder in which the body creates antibodies against phospholipids (normal components of human blood cells). Accordingly, lupus anticoagulant and other antiphospholipid antibodies can cause tiny blood…