What was Phthalimide used for?

Phthalimide is used as a precursor to anthranilic acid, a precursor to azo dyes and saccharin. Alkyl phthalimides are useful precursors to amines in chemical synthesis, especially in peptide synthesis where they are used “to block both hydrogens and avoid racemization of the substrates”.

How to synthesis phthalimide?

An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low temperatures (20-70˚C). The employment of microwave irradiation presents noteworthy advantages over conventional heating.

Is Phthalimide aromatic?

Introduction to Phthalimide – C₆H₄(CO₂)NH. It is an organic aromatic compound with the chemical formula C6H4(CO2)NH. It has a heteroatom Nitrogen present in it.

Is Benzylamine A?

Benzylamine is an organic chemical compound with the condensed structural formula C6H5CH2NH2 (sometimes abbreviated as PhCH2NH2 or BnNH2). This colorless water-soluble liquid is a common precursor in organic chemistry and used in the industrial production of many pharmaceuticals.

What kind of dye is phthalic anhydride used for?

Quinoline Yellow SS is a popular dye derived from the condensation of phthalic anhydride and 2-methylquinoline. Phthalic anhydride is widely used in industry for the production of certain dyes.

How is phthalimide prepared from phthalic anhydride?

Phthalimide can be prepared by heating phthalic anhydride with aqueous ammonia giving 95–97% yield. Alternatively, it may be prepared by treating the anhydride with ammonium carbonate or urea. It can also be produced by ammoxidation of o-xylene.

How is phthalic anhydride treated with cellulose acetate?

Phthalic anhydride treated with cellulose acetate gives cellulose acetate phthalate (CAP), a common enteric coating excipient that has also been shown to have antiviral activity. Phthalic anhydride is a degradation product of CAP.

How is phthalic anhydride harmful to the human body?

The most probable human exposure to phthalic anhydride is through skin contact or inhalation during manufacture or use. Studies show that exposure to phthalic anhydride can cause rhinitis, chronic bronchitis, and asthma.